Chitosan composite scaffolds for articular cartilage defect repair: a review,RSC Advances

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Chitosan composite scaffolds for articular cartilage defect repair: a review
RSC Advances ( IF 3.9 ) Pub Date : 2018-01-19 00:00:00 , DOI: 10.1039/c7ra11593h
Huijun Li _{1,

2,

3,

4} , Cheng Hu _{1,

4} , Huijun Yu _{1,

2,

3} , Chuanzhong Chen _{1,

4}

Affiliation

Articular cartilage (AC) defects lack the ability to self-repair due to their avascular nature and the declined mitotic ability of mature chondrocytes. To date, cartilage tissue engineering using implanted scaffolds containing cells or growth factors is the most promising defect repair method. Scaffolds for cartilage tissue engineering have been comprehensively researched. As a promising scaffold biomaterial for AC defect repair, the properties of chitosan are summarized in this review. Strategies to composite chitosan with other materials, such as polymers (including collagen, gelatin, alginate, silk fibroin, poly-caprolactone, and poly-lactic acid) and bioceramics (including calcium phosphate, calcium polyphosphate, and hydroxyapatite) are presented. Methods to manufacture three-dimensional porous structures to support cell attachment and nutriment exchange have also been included.

中文翻译：

用于关节软骨缺损修复的壳聚糖复合支架：综述

关节软骨 (AC) 缺损由于其无血管性质和成熟软骨细胞的有丝分裂能力下降而缺乏自我修复的能力。迄今为止，使用含有细胞或生长因子的植入支架的软骨组织工程是最有希望的缺陷修复方法。对软骨组织工程支架进行了全面研究。作为一种有前途的用于修复 AC 缺陷的支架生物材料，本综述总结了壳聚糖的特性。提出了将壳聚糖与其他材料复合的策略，例如聚合物（包括胶原蛋白、明胶、藻酸盐、丝素蛋白、聚己内酯和聚乳酸）和生物陶瓷（包括磷酸钙、多磷酸钙和羟基磷灰石）。

更新日期：2018-01-19

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