Glioma‐Targeted Delivery of a Theranostic Liposome Integrated with Quantum Dots, Superparamagnetic Iron Oxide, and Cilengitide for Dual‐Imaging Guiding Cancer Surgery,Advanced Healthcare Materials

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Glioma‐Targeted Delivery of a Theranostic Liposome Integrated with Quantum Dots, Superparamagnetic Iron Oxide, and Cilengitide for Dual‐Imaging Guiding Cancer Surgery
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2018-01-19 , DOI: 10.1002/adhm.201701130
He-Lin Xu ₁ , Jing-Jing Yang ₁ , De-Li ZhuGe ₁ , Meng-Ting Lin ₁ , Qun-Yan Zhu ₁ , Bing-Hui Jin ₁ , Meng-Qi Tong ₁ , Bi-Xin Shen ₁ , Jian Xiao ₂ , Ying-Zheng Zhao ₁

Affiliation

Herein, a theranostic liposome (QSC‐Lip) integrated with superparamagnetic iron oxide nanoparticles (SPIONs) and quantum dots (QDs) and cilengitide (CGT) into one platform is constructed to target glioma under magnetic targeting (MT) for guiding surgical resection of glioma. Transmission electron microscopy and X‐ray photoelectron spectroscopy confirm the complete coencapsulation of SPIONs and QDs in liposome. Besides, CGT is also effectively encapsulated into the liposome with an encapsulation efficiency of ∼88.9%. QSC‐Lip exhibits a diameter of 100 ± 1.24 nm, zeta potential of −17.10 ± 0.11 mV, and good stability in several mediums. Moreover, each cargo shows a biphasic release pattern from QSC‐Lip, a rapid initial release within initial 10 h followed by a sustained release. Cellular uptake of QSC‐Lip is significantly enhanced by C₆ cells under MT. In vivo dual‐imaging studies show that QSC‐Lip not only produces an obvious negative‐contrast enhancement effect on glioma by magnetic resonance imaging but also makes tumor emitting fluorescence under MT. The dual‐imaging of QSC‐Lip guides the accurate resection of glioma by surgery. Besides, CGT is also specifically distributed to glioma after administration of QSC‐Lip under MT, resulting in an effective inhibition of tumors. The integrated liposome may be a potential carrier for theranostics of tumor.

中文翻译：

胶质瘤靶向的治疗性脂质体与量子点，超顺磁性氧化铁和西格列肽的结合，用于双成像指导癌症手术。

在本文中，构建了将超顺磁性氧化铁纳米粒子（SPIONs）和量子点（QDs）和西仑吉肽（CGT）整合为一个平台的治疗性脂质体（QSC-Lip），以在磁性靶向（MT）下靶向神经胶质瘤，以指导神经胶质瘤的手术切除。透射电子显微镜和X射线光电子能谱证实了脂质体中SPION和QD的完全共包封。此外，CGT还可以有效包裹到脂质体中，包裹效率约为88.9％。QSC-Lip的直径为100±1.24 nm，ζ电势为−17.10±0.11 mV，在多种介质中均具有良好的稳定性。此外，每件货物均表现出QSC-Lip的双相释放模式，在最初的10小时内迅速释放，然后持续释放。C显着增强了QSC-Lip的细胞摄取MT下_6个细胞。体内双成像研究表明，QSC-Lip不仅可以通过磁共振成像对神经胶质瘤产生明显的负对比度增强作用，还可以使肿瘤在MT下发出荧光。QSC-Lip的双重成像可指导通过手术准确切除神经胶质瘤。此外，在MT下施用QSC-Lip后，CGT还专门分布于神经胶质瘤，从而有效抑制了肿瘤。整合的脂质体可能是肿瘤治疗学的潜在载体。

更新日期：2018-01-19

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