This pilot study aimed to investigate the utility of near-infrared spectroscopy/indocyanine green (NIRS/ICG) for examining patients with occlusive cerebrovascular disease. Twenty-nine patients with chronic-stage atherosclerotic occlusive cerebrovascular disease were included. The patients were monitored using NIRS at the bedside. Using ICG time-intensity curves, the affected-to-unaffected side ratios were calculated for several parameters, including the maximum ICG concentration (ΔICGmax), time to peak (TTP), rise time (RT), and blood flow index (BFI = ΔICGmax/RT), and were compared to the affected-to-unaffected side ratios of the regional cerebral blood flow (rCBF) and regional oxygen extraction fraction (rOEF) obtained using positron emission tomography with ¹⁵O-labeled gas. The BFI ratio showed the best correlation with the rCBF ratio among these parameters (r = 0.618; P = 0.0004), and the RT ratio showed the best correlation with the rOEF ratio (r = 0.593; P = 0.0007). The patients were further divided into reduced rCBF or elevated rOEF groups, and the analysis revealed significant related differences. The present results advance the measurement of ICG kinetics using NIRS as a useful tool for the detection of severely impaired perfusion with reduced rCBF or elevated rOEF. This method may be applicable as a monitoring tool for patients with acute ischemic stroke.

中文翻译：

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在动脉粥样硬化闭塞性疾病患者中使用近红外光谱和吲哚菁绿在床旁评估区域性脑灌注。

这项初步研究旨在研究近红外光谱/吲哚菁绿（NIRS / ICG）在检查闭塞性脑血管疾病患者中的效用。包括二十九位患有慢性动脉粥样硬化闭塞性脑血管疾病的患者。使用床边的NIRS对患者进行监测。使用ICG时间强度曲线，计算了几个参数的受影响/未受影响的侧面比，包括最大ICG浓度（ΔICGmax），峰化时间（TTP），上升时间（RT）和血流指数（BFI = ΔICGmax/ RT），并与使用¹⁵倍正电子发射断层扫描获得的区域脑血流量（rCBF）和区域氧提取分数（rOEF）的受影响/未受影响侧比进行比较O标记的气体。在这些参数中，BFI比率与rCBF比率显示出最佳相关性（r = 0.618； P = 0.0004），而RT比率与rOEF比率显示出最佳相关性（r = 0.593； P = 0.0007）。将患者进一步分为降低的rCBF组或升高的rOEF组，分析显示出显着的相关差异。目前的结果促进了使用NIRS作为检测rCBF降低或rOEF升高的严重受损灌注的有用工具进行ICG动力学的测量。该方法可用作急性缺血性卒中患者的监测工具。