In this issue ofCell Chemical Biology,Bondeson et al., 2018,Burslem et al., 2018Burslem G.M.Smith B.E.Lai A.C.Jaime-Figueroa S.McQuaid D.C.Bondeson D.P.Toure M.Dong H.Qian Y.Wang J.et al.The advantages of targeted protein degradation over inhibition: an RTK case study.Cell Chem Biol.2018;25(this issue):67-77AbstractFull TextFull Text PDFPubMedScopus (11)Google Scholar, andHuang et al. (2018)Huang H.T.Dobrovolsky D.Paulk J.Yang G.Weisberg E.L.Doctor Z.M.Buckley D.L.Cho J.H.Ko E.Jang J.et al.A chemoproteomic approach to query the degradable kinome using a multi-kinase degrader.Cell Chem Biol.2018;25(this issue):88-99AbstractFull TextFull Text PDFPubMedScopus (16)Google Scholarsystematically characterize proteolysis-targeting chimeras (PROTACs) regarding their specificity and general advantages of targeted proteolysis of cellular proteins and provide interesting insights into possible future developments. In this issue ofCell Chemical Biology,Bondeson et al., 2018,Burslem et al., 2018, andHuang et al. (2018)Huang H.T.Dobrovolsky D.Paulk J.Yang G.Weisberg E.L.Doctor Z.M.Buckley D.L.Cho J.H.Ko E.Jang J.et al.A chemoproteomic approach to query the degradable kinome using a multi-kinase degrader.Cell Chem Biol.2018;25(this issue):88-99AbstractFull TextFull Text PDFPubMedScopus (16)Google Scholarsystematically characterize proteolysis-targeting chimeras (PROTACs) regarding their specificity and general advantages of targeted proteolysis of cellular proteins and provide interesting insights into possible future developments.

中文翻译：

---

试试我：混杂抑制剂仍然允许选择性靶向的蛋白质降解

本期《细胞化学生物学》（Bondeson等，2018，Burslem等，2018）Burslem GMSmith BELai ACJaime-Figueroa S.McQuaid DCBondeson DP Toure M.Dong H.Qian Y.Wang J.et al。靶向蛋白质降解的优势过度抑制：RTK案例研究.Cell Chem Biol.2018; 25（本期）：67-77AbstractFull TextFull TextPDFPubMedScopus（11）Google Scholar和Huang等人。（2018）Huang HT Dobrovolsky D.Paulk J.Yang G.Weisberg ELDoctor ZMBuckley DLCho JHKo E.Jang J.et al。问题）：88-99AbstractFull TextFull Text PDFPubMedScopus（16）Google Scholar系统分析了靶向蛋白水解嵌合体（PROTAC）的特异性和细胞蛋白靶向蛋白水解的一般优势，并为可能的未来发展提供了有趣的见解。在本期《细胞化学生物学》（Bondeson et al。，2018，Burslem et al。，2018，and Huang et al。（2018）Huang HT Dobrovolsky D.Paulk J.Yang G.Weisberg ELDoctor ZMBuckley DLCho JHKo E.Jang J.et al。问题）：