Wearable bendable bandage‐based sensor and a minimally invasive microneedle biosensor are described toward rapid screening of skin melanoma. These wearable electrochemical sensors are capable of detecting the presence of the tyrosinase (TYR) enzyme cancer biomarker in the presence of its catechol substrate, immobilized on the transducer surface. In the presence of the surface TYR biomarker, the immobilized catechol is rapidly converted to benzoquinone that is detected amperometrically, with a current signal proportional to the TYR level. The flexible epidermal bandage sensor relies on printing stress‐enduring inks which display good resiliency against mechanical deformations, whereas the hollow microneedle device is filled with catechol‐coated carbon paste for assessing tissue TYR levels. The bandage sensor can thus be used directly on the skin whereas microneedle device can reach melanoma tissues under the skin. Both wearable sensors are interfaced to an ultralight flexible electronic board, which transmits data wirelessly to a mobile device. The analytical performance of the resulting bandage and microneedle sensing systems are evaluated using TYR‐containing agarose phantom gel and porcine skin. The new integrated conformal portable sensing platforms hold considerable promise for decentralized melanoma screening, and can be extended to the screening of other key biomarkers in skin moles.

中文翻译：

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穿戴式无线酪氨酸酶绷带和微针传感器：黑色素瘤筛查

描述了基于可弯曲绷带的可穿戴传感器和微创微针生物传感器，旨在快速筛查皮肤黑色素瘤。这些可穿戴的电化学传感器能够在固定在换能器表面上的邻苯二酚底物存在的情况下检测酪氨酸酶（TYR）酶癌生物标志物的存在。在表面TYR生物标志物的存在下，固定的邻苯二酚会迅速转化为苯并醌，该苯醌在安培法下可以检测到，电流信号与TYR水平成正比。柔性表皮绷带传感器依靠可承受压力的油墨印刷，这些油墨对机械变形显示出良好的回弹力，而空心微针装置中则填充有儿茶酚涂层碳糊以评估组织的TYR水平。绷带传感器因此可以直接在皮肤上使用，而微针设备可以到达皮肤下的黑色素瘤组织。两个可穿戴传感器均连接至超轻柔性电子板，该板可将数据无线传输至移动设备。使用含TYR的琼脂糖体模凝胶和猪皮肤评估所得绷带和微针传感系统的分析性能。新的整合式共形便携式传感平台在分散型黑色素瘤筛查中具有广阔的前景，并可扩展到皮肤痣中其他关键生物标志物的筛查。使用含TYR的琼脂糖体模凝胶和猪皮肤评估所得绷带和微针传感系统的分析性能。新的整合式共形便携式传感平台在分散型黑色素瘤筛查中具有广阔的前景，并可扩展到皮肤痣中其他关键生物标志物的筛查。使用含TYR的琼脂糖体模凝胶和猪皮肤评估所得绷带和微针传感系统的分析性能。新的整合式共形便携式传感平台在分散型黑色素瘤筛查中具有广阔的前景，并可扩展到皮肤痣中其他关键生物标志物的筛查。