Wearable Wireless Tyrosinase Bandage and Microneedle Sensors: Toward Melanoma Screening,Advanced Healthcare Materials

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Wearable Wireless Tyrosinase Bandage and Microneedle Sensors: Toward Melanoma Screening
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2018-01-18 , DOI: 10.1002/adhm.201701264
Bianca Ciui _{1,

2} , Aida Martin ₁ , Rupesh K Mishra ₁ , Barbara Brunetti _{1,

3} , Tatsuo Nakagawa ₁ , Thomas J Dawkins ₁ , Mengjia Lyu ₁ , Cecilia Cristea ₂ , Robert Sandulescu ₂ , Joseph Wang ₁

Affiliation

Wearable bendable bandage‐based sensor and a minimally invasive microneedle biosensor are described toward rapid screening of skin melanoma. These wearable electrochemical sensors are capable of detecting the presence of the tyrosinase (TYR) enzyme cancer biomarker in the presence of its catechol substrate, immobilized on the transducer surface. In the presence of the surface TYR biomarker, the immobilized catechol is rapidly converted to benzoquinone that is detected amperometrically, with a current signal proportional to the TYR level. The flexible epidermal bandage sensor relies on printing stress‐enduring inks which display good resiliency against mechanical deformations, whereas the hollow microneedle device is filled with catechol‐coated carbon paste for assessing tissue TYR levels. The bandage sensor can thus be used directly on the skin whereas microneedle device can reach melanoma tissues under the skin. Both wearable sensors are interfaced to an ultralight flexible electronic board, which transmits data wirelessly to a mobile device. The analytical performance of the resulting bandage and microneedle sensing systems are evaluated using TYR‐containing agarose phantom gel and porcine skin. The new integrated conformal portable sensing platforms hold considerable promise for decentralized melanoma screening, and can be extended to the screening of other key biomarkers in skin moles.

中文翻译：

可穿戴无线酪氨酸酶绷带和微针传感器：迈向黑色素瘤筛查

描述了基于可穿戴式可弯曲绷带的传感器和微创微针生物传感器，用于快速筛查皮肤黑色素瘤。这些可穿戴电化学传感器能够在固定于传感器表面的儿茶酚底物存在的情况下检测酪氨酸酶 (TYR) 酶癌症生物标志物的存在。在表面 TYR 生物标记物存在的情况下，固定的儿茶酚迅速转化为苯醌，苯醌可通过电流检测，电流信号与 TYR 水平成比例。柔性表皮绷带传感器依赖于印刷耐应力墨水，这种墨水对机械变形表现出良好的弹性，而空心微针装置则填充有儿茶酚涂层的碳糊，用于评估组织 TYR 水平。因此，绷带传感器可以直接在皮肤上使用，而微针装置可以到达皮肤下的黑色素瘤组织。两个可穿戴传感器都与超轻柔性电子板连接，该电子板将数据无线传输到移动设备。使用含有 TYR 的琼脂糖模型凝胶和猪皮评估所得绷带和微针传感系统的分析性能。新的集成适形便携式传感平台为分散式黑色素瘤筛查带来了巨大的希望，并且可以扩展到皮肤痣中其他关键生物标志物的筛查。

更新日期：2018-01-18

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