Engineering 3D Hydrogels for Personalized In Vitro Human Tissue Models,Advanced Healthcare Materials

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Engineering 3D Hydrogels for Personalized In Vitro Human Tissue Models
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2018-01-18 , DOI: 10.1002/adhm.201701165
Chya-Yan Liaw ₁ , Shen Ji ₁ , Murat Guvendiren ₁

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There is a growing interest in engineering hydrogels for 3D tissue and disease models. The major motivation is to better mimic the physiological microenvironment of the disease and human condition. 3D tissue models derived from patients' own cells can potentially revolutionize the way treatment and diagnostic alternatives are developed. This requires development of tissue mimetic hydrogels with user defined and tunable properties. In this review article, a recent summary of 3D hydrogel platforms for in vitro tissue and disease modeling is given. Hydrogel design considerations and available hydrogel systems are summarized, followed by the types of currently available hydrogel models, such as bulk hydrogels, porous scaffolds, fibrous scaffolds, hydrogel microspheres, hydrogel sandwich systems, microwells, and 3D bioprinted constructs. Although hydrogels are utilized for a wide range of tissue models, this article focuses on liver and cancer models. This article also provides a detailed section on current challenges and future perspectives of hydrogel‐based tissue models.

中文翻译：

用于个性化体外人体组织模型的工程3D水凝胶

对用于3D组织和疾病模型的工程水凝胶的兴趣与日俱增。主要动机是更好地模拟疾病和人类状况的生理微环境。源自患者自身细胞的3D组织模型可能会彻底改变治疗和诊断替代方案的开发方式。这就需要开发具有用户定义和可调特性的组织模拟水凝胶。在这篇综述文章中，提供了用于体外组织和疾病建模的3D水凝胶平台的最新摘要。总结了水凝胶的设计考虑因素和可用的水凝胶系统，然后概述了当前可用的水凝胶模型的类型，例如本体水凝胶，多孔支架，纤维支架，水凝胶微球，水凝胶夹心系统，微孔和3D生物打印结构。尽管水凝胶可用于多种组织模型，但本文重点关注肝脏和癌症模型。本文还详细介绍了基于水凝胶的组织模型的当前挑战和未来前景。

更新日期：2018-01-18

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