The first total synthesis of parvifloron F, a bioactive highly oxidized abietane diterpene, was achieved. The abietane skeleton was constructed by Lewis acid promoted cyclization. Preliminary structure–activity relationship correlations were established for the synthetic intermediates against human tumor cell lines. Certain compounds showed unique selective antiproliferative activity against triple-negative breast cancer. The oxidation level of the abietane ring affected the selectivity.

中文翻译：

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抗增殖Parvifloron F的全合成

Parvifloron F是一种具有生物活性的高度氧化的枞树碱二萜，它是第一个完全合成的化合物。通过路易斯酸促进的环化作用构建了abinetane骨架。建立了针对人类肿瘤细胞系的合成中间体的初步构效关系。某些化合物对三阴性乳腺癌显示出独特的选择性抗增殖活性。松果烷环的氧化水平影响选择性。