The first total synthesis of (+)-epigalcatin was completed in a highly stereoselective manner starting from piperonal, 3,4-dimethylbenzaldehyde, and diethyl succinate. l-Prolinol was used as a chiral auxiliary. The crucial step in this procedure involves the construction of the cyclolignan framework by continuous-flow photocyclization of a chiral atropisomeric 1,2-bisbenzylidenesuccinate amide ester.

中文翻译：

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流动光化学作为（+）-表甜抗素全合成的工具

（+）-表皮角质素的第一个全合成是从胡椒醛，3,4-二甲基苯甲醛和琥珀酸二乙酯以高度立体选择性的方式完成的。1-脯氨醇用作手性助剂。该方法中的关键步骤涉及通过手性阻转异构体1,2-双亚苄基琥珀酸酰胺酯的连续流动光环化来构建环木聚糖骨架。