One-pot synthesis of a fluorescent molecularly imprinted nanosensor for highly selective detection of sulfapyridine in water,Analytical Methods

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One-pot synthesis of a fluorescent molecularly imprinted nanosensor for highly selective detection of sulfapyridine in water
Analytical Methods ( IF 2.7 ) Pub Date : 2018-01-18 00:00:00 , DOI: 10.1039/c7ay02872e
Yufeng Hu _{1,

2,

3,

4} , Xiangdao Li _{1,

2,

3,

4} , Jie Liu _{1,

2,

3,

4} , Minghuo Wu _{1,

2,

3,

4} , Ming Li _{4,

5,

6,

7,

8} , Xinke Zang _{1,

2,

3,

4}

Affiliation

Fluorescent molecularly imprinted polymers (FMIPs) were prepared in a one-pot synthesis using Mn-doped ZnS quantum dots (QDs) as a fluorescent core, sulfapyridine (SPD) as a template, methacrylic acid as a functional monomer, and ethylene glycol dimethacrylate as a cross-linker for a free-radical polymerization process. These FMIPs could be used for sensing SPD based on fluorescence quenching. As the concentration of Mn²⁺ in the QDs changed, the fluorescence response of the FMIPs toward SPD also varied. The optimum concentration of Mn²⁺ for the preparation of Mn-doped ZnS QDs was 2.5 mmol. Under the optimum conditions, the obtained FMIPs showed good binding capacity and high selectivity, and specificity toward SPD. The fluorescence intensity of the FMIPs decreased as the concentration of SPD increased in the range of 0–80 μM, with a detection limit of 0.5 μM. The FMIPs exhibited selectivity towards SPD over its structural analogs sulfanilamide, sulfathiazole, sulfamethoxazole, sulfadiazine, sulfamerazine, sulfamethazine, and sulfacetamide. Finally, the FMIPs were successfully applied to detect SPD in tap water samples, and the average recoveries of SPD at three spiking levels ranged from 95.6% to 99.8% with relative standard deviations below 1.4%. This work provides a free-radical polymerization fabrication method for fluorescent MIP sensors, which can be used for rapid recognition and determination of sulfonamides from complex matrices.

中文翻译：

一锅合成的荧光分子印迹纳米传感器，用于高选择性检测水中的磺胺吡啶

使用锰掺杂的ZnS量子点（QD）作为荧光核，磺胺吡啶（SPD）作为模板，甲基丙烯酸作为功能单体以及乙二醇二甲基丙烯酸酯作为一锅合成法制备荧光分子印迹聚合物（FMIP）。自由基聚合过程的交联剂。这些FMIP可用于基于荧光猝灭的SPD感测。随着量子点中Mn ²⁺浓度的变化，FMIP对SPD的荧光响应也发生了变化。Mn ²⁺的最佳浓度制备Mn掺杂的ZnS的QDs为2.5 mmol。在最佳条件下，所得的FMIPs显示出良好的结合能力和高选择性，以及对SPD的特异性。FMIPs的荧光强度随SPD浓度的增加在0-80μM范围内降低，检出限为0.5μM。相对于其结构类似物磺胺，磺胺噻唑，磺胺甲恶唑，磺胺嘧啶，磺胺嘧啶，磺胺二甲嘧啶和磺胺乙酰胺，FMIPs对SPD表现出选择性。最终，FMIPs成功地应用于自来水样品中SPD的检测，三种加标水平下SPD的平均回收率在95.6％至99.8％之间，相对标准偏差低于1.4％。这项工作为荧光MIP传感器提供了一种自由基聚合的制备方法，

更新日期：2018-01-18

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