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Composite Bijel-Templated Hydrogels for Cell Delivery
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2018-02-01 00:00:00 , DOI: 10.1021/acsbiomaterials.7b00809 Todd J Thorson 1 , Elliot L Botvinick 2 , Ali Mohraz 1
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2018-02-01 00:00:00 , DOI: 10.1021/acsbiomaterials.7b00809 Todd J Thorson 1 , Elliot L Botvinick 2 , Ali Mohraz 1
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Numerous processing techniques aim to impart interconnected, porous structures within regenerative medicine materials to support cell delivery and direct tissue growth. Many of these techniques lack predictable control of scaffold architecture, and rapid prototyping methods are often limited by time-consuming, layer-by-layer fabrication of microfeatures. Bicontinuous interfacially jammed emulsion gels (bijels) offer a robust, self-assembly based platform for synthesizing a new class of morphologically unique cell delivery biomaterials. Bijels form via kinetic arrest of temperature-driven spinodal decomposition in partially miscible binary liquid systems. These nonequilibrium soft materials comprise cocontinuous, fully interpenetrating, nonconstricting liquid domains separated by a nanoparticle monolayer. Through the selective introduction of biocompatible precursors, hydrogel scaffolds displaying the morphological characteristics of the parent bijel can be formed. We report using bijel templating to generate structurally unique, fibrin-loaded polyethylene glycol hydrogel composites. Demonstration of composite bijel-templated hydrogels (CBiTHs) as a new cell delivery system was carried out in vitro using fluorescence-based tracking of cells delivered to previously acellular fibrin gels. Imaging analysis confirmed repeatable delivery of normal human dermal fibroblasts to acellular fibrin gels.
中文翻译：
用于细胞递送的复合 Bijel 模板水凝胶
许多加工技术旨在在再生医学材料中赋予互连的多孔结构，以支持细胞输送和指导组织生长。其中许多技术缺乏对支架结构的可预测控制，并且快速原型制作方法通常受到耗时、逐层制造微观特征的限制。双连续界面堵塞乳液凝胶（bijels）提供了一个强大的、基于自组装的平台，用于合成新型形态独特的细胞递送生物材料。Bijels 通过在部分混溶的二元液体系统中温度驱动的旋节线分解的动力学停止而形成。这些非平衡软材料包含由纳米颗粒单层分隔的共连续、完全互穿、非收缩的液体域。通过选择性引入生物相容性前体，可以形成显示母体 bijel 形态特征的水凝胶支架。我们报告使用 bijel 模板来生成结构独特的、负载纤维蛋白的聚乙二醇水凝胶复合材料。复合双杰尔模板水凝胶（CBiTH）作为一种新的细胞递送系统的演示是在体外使用基于荧光的跟踪递送到先前的无细胞纤维蛋白凝胶的细胞进行的。成像分析证实正常人真皮成纤维细胞可重复递送至无细胞纤维蛋白凝胶。
更新日期：2018-02-01
中文翻译：
用于细胞递送的复合 Bijel 模板水凝胶
许多加工技术旨在在再生医学材料中赋予互连的多孔结构，以支持细胞输送和指导组织生长。其中许多技术缺乏对支架结构的可预测控制，并且快速原型制作方法通常受到耗时、逐层制造微观特征的限制。双连续界面堵塞乳液凝胶（bijels）提供了一个强大的、基于自组装的平台，用于合成新型形态独特的细胞递送生物材料。Bijels 通过在部分混溶的二元液体系统中温度驱动的旋节线分解的动力学停止而形成。这些非平衡软材料包含由纳米颗粒单层分隔的共连续、完全互穿、非收缩的液体域。通过选择性引入生物相容性前体，可以形成显示母体 bijel 形态特征的水凝胶支架。我们报告使用 bijel 模板来生成结构独特的、负载纤维蛋白的聚乙二醇水凝胶复合材料。复合双杰尔模板水凝胶（CBiTH）作为一种新的细胞递送系统的演示是在体外使用基于荧光的跟踪递送到先前的无细胞纤维蛋白凝胶的细胞进行的。成像分析证实正常人真皮成纤维细胞可重复递送至无细胞纤维蛋白凝胶。
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