A single and simple ortho‐sulfonyl benzonitrile template was developed to achieve remote C−H olefination of six different classes of N‐heterocycles. We demonstrate that, by varying precatalysts and conditions, the same template can be applied to the remote C−H activation of six structurally distinct heterocyclic scaffolds, and the site‐selectivity can be predicted based on distance and geometry. Furthermore, this new development shows that template‐directed remote C−H activation is possible through macrocyclopalladation processes with smaller ring sizes.

中文翻译：

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使用单个模板的各种N-杂环的远程CH-H激活

开发了一个简单的邻磺酰基苯甲腈模板，以实现六种不同类别的N-杂环的远程CH H烯化反应。我们证明，通过改变预催化剂和条件，相同的模板可以应用于六个结构上不同的杂环支架的远程CH活化，并且可以根据距离和几何形状预测位点选择性。此外，这项新进展表明，通过具有较小环尺寸的大环palpalpalation过程，可以进行模板定向的远程CH活化。