A lab-scale anoxic/oxic-membrane bioreactor was designed to treat antibiotics containing wastewater at different antibiotics concentrations (0.5 mg/L, 1 mg/L and 3 mg/L of each antibiotic). Overall COD and NH₄⁺

N removal (more than 90%) were not affected during the exposure to antibiotics and good TN removal was also achieved, while TP removal was significantly affected. The maximum removal efficiency of penicillin and chlorotetracycline reached 97.15% and 96.10% respectively due to strong hydrolysis, and sulfamethoxazole reached 90.07% by biodegradation. However, 63.87% of norfloxacin maximum removal efficiency was achieved mainly by sorption. The system had good ability to reduce ARGs, peaking to more than 4 orders of magnitude, which mainly depended on the biomass retaining of the membrane module. Antibiotics concentration influenced the evolution of ARGs and bacterial communities in the reactor. This research provides great implication to reduce ARGs and antibiotics in antibiotics containing wastewater using A/O-MBR.

中文翻译：

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深入了解抗生素对膜反应器中反应器性能的影响以及抗生素抗性基因和微生物群落的演变

设计了实验室规模的缺氧/缺氧膜生物反应器，以处理不同抗生素浓度（每种抗生素分别为0.5 mg / L，1 mg / L和3 mg / L）中含有废水的抗生素。总COD和NH ₄ ⁺

暴露于抗生素过程中氮的去除率（超过90％）没有受到影响，总氮的去除也很不错，而总磷的去除却受到了很大的影响。由于强水解作用，青霉素和氯四环素的最大去除率分别达到97.15％和96.10％，而磺胺甲恶唑通过生物降解达到90.07％。但是，诺氟沙星的最大去除效率为63.87％，这主要是通过吸附实现的。该系统具有良好的降低ARG的能力，最高可达到4个数量级以上，这主要取决于膜组件的生物量保留能力。抗生素浓度影响反应堆中ARG的进化和细菌群落。这项研究对使用A / O-MBR减少含抗生素废水中的ARGs和抗生素具有重要意义。