Household-Contact Investigation for Detection of Tuberculosis in Vietnam,The New England Journal of Medicine

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Household-Contact Investigation for Detection of Tuberculosis in Vietnam
The New England Journal of Medicine ( IF 96.2 ) Pub Date : 2018-01-17 , DOI: 10.1056/nejmoa1700209
Greg J. Fox ₁ , Nguyen V. Nhung ₁ , Dinh N. Sy ₁ , Nghiem L.P. Hoa ₁ , Le T.N. Anh ₁ , Nguyen T. Anh ₁ , Nguyen B. Hoa ₁ , Nguyen H. Dung ₁ , Tran N. Buu ₁ , Nguyen T. Loi ₁ , Le T. Nhung ₁ , Nguyen V. Hung ₁ , Phan T. Lieu ₁ , Nguyen K. Cuong ₁ , Pham D. Cuong ₁ , Jessica Bestrashniy ₁ , Warwick J. Britton ₁ , Guy B. Marks ₁

Affiliation

BackgroundActive case finding is a top priority for the global control of tuberculosis, but robust evidence for its effectiveness in high-prevalence settings is lacking. We sought to evaluate the effectiveness of household-contact investigation, as compared with standard, passive measures alone, in Vietnam. MethodsWe performed a cluster-randomized, controlled trial at clinics in 70 districts (local government areas with an average population of approximately 500,000 in urban areas and 100,000 in rural areas) in eight provinces of Vietnam. Health workers at each district clinic or hospital were assigned to perform either household-contact intervention plus standard passive case finding (intervention group) or passive case finding alone (control group). In the intervention districts, household contacts of patients with positive results for tuberculosis on sputum smear microscopy (smear-positive tuberculosis) were invited for clinical assessment and chest radiography at baseline and at 6, 12, and 24 months. ...

中文翻译：

在越南进行结核病家庭接触调查

背景技术主动寻找病例是全球控制结核病的重中之重，但缺乏在高流行地区有效的确凿证据。我们试图评估与单独的标准被动措施相比，越南的家庭接触调查的有效性。方法我们在越南8个省的70个地区（城市地区平均人口约为500,000，农村地区平均人口为100,000）的诊所进行了一项集群随机对照试验。分配给每个地区诊所或医院的卫生工作者进行家庭接触干预加上标准的被动病例发现（干预组）或单独进行被动病例发现（对照组）。在干预区，邀请在痰涂片镜检（涂片阳性结核）上结核病阳性的患者进行家庭接触，以在基线，第6、12和24个月进行临床评估和胸部X线摄影。...

更新日期：2018-01-18

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