Hedychins A and B, 6,7-Dinorlabdane Diterpenoids with a Peroxide Bridge from Hedychium forrestii,Organic Letters

当前位置： X-MOL 学术 › Org. Lett. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Hedychins A and B, 6,7-Dinorlabdane Diterpenoids with a Peroxide Bridge from Hedychium forrestii
Organic Letters ( IF 4.9 ) Pub Date : 2018-01-17 00:00:00 , DOI: 10.1021/acs.orglett.7b03836
Qing Zhao ₁ , Jie-Jie Gao ₁ , Xu-Jie Qin ₂ , Xiao-Jiang Hao ₂ , Hong-Ping He _{1,

2} , Hai-Yang Liu ₂

Affiliation

Hedychins A (1) and B (2), two unprecedented 6,7-dinorlabdane ditepenoids with a peroxide bridge, were obtained from the rhizomes of Hedychium forrestii. Their structures and absolute configurations were unequivocally established by a combination of spectroscopic data and X-ray single-crystal diffractions. Their plausible biosynthetic pathway was proposed. Compound 2 exhibited cytotoxicity against HepG2 and XWLC-05 cell lines with IC₅₀ values of 8.0 and 19.7 μM, respectively.

中文翻译：

Hedychium forrestii的Hedychins A和B，带有过氧化物桥的6,7-二去拉丹烷二萜

Hedychins A（1）和B（2）是从Hedychium forrestii的根茎中获得的两种前所未有的带有过氧化物桥的6,7-二氮杂丹烷二萜类化合物。通过光谱数据和X射线单晶衍射的结合明确地确定了它们的结构和绝对构型。提出了它们可能的生物合成途径。化合物2对HepG2和XWLC-05细胞系表现出细胞毒性，IC ₅₀值分别为8.0和19.7μM。

更新日期：2018-01-17

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11