Ru(II)-Catalyzed Oxidative Heck-Type Olefination of Aromatic Carboxylic Acids with Styrenes through Carboxylate-Assisted C–H Bond Activation,Organic Letters

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Ru(II)-Catalyzed Oxidative Heck-Type Olefination of Aromatic Carboxylic Acids with Styrenes through Carboxylate-Assisted C–H Bond Activation
Organic Letters ( IF 4.9 ) Pub Date : 2018-01-17 00:00:00 , DOI: 10.1021/acs.orglett.7b03852
Suman Dana ₁ , Anup Mandal ₁ , Harekrishna Sahoo ₁ , Sumitava Mallik ₁ , Gowri Sankar Grandhi ₁ , Mahiuddin Baidya ₁

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A straightforward synthesis of 2-styrylbenzoic acids from aryl carboxylic acids is disclosed through a carboxylate-assisted coupling under Ru(II) catalysis. This protocol is simple and exhibits broad scope with high tolerance of common organic functional groups, providing good to excellent yields of diverse olefinated products. The efficacy of this protocol has been showcased through sequential syntheses of isochromanone, isocoumarin, and formal synthesis of anacardic acid derivative in good yields.

中文翻译：

Ru（II）通过羧酸盐辅助的C–H键活化催化苯乙烯与苯乙烯的氧化Heck型烯烃氧化

通过Ru（II）催化下的羧酸盐辅助偶联，公开了由芳基羧酸直接合成2-苯乙烯基苯甲酸的方法。该方案简单易行，具有广泛的应用范围，对常见的有机官能团具有较高的耐受性，可提供多种多样的烯烃化产物良好的收率。该协议的功效已通过异色蒽酮，异香豆素的顺序合成以及以高收率正式合成的漆树酸衍生物得到了证明。

更新日期：2018-01-17

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