The morbidity and socioeconomic effects of onchocerciasis, a parasitic disease that is primarily endemic in sub-Saharan Africa, have motivated large morbidity and transmission control programmes. Annual community-directed ivermectin treatment has substantially reduced prevalence. Elimination requires intensified efforts, including more efficacious treatments. We compared parasitological efficacy and safety of moxidectin and ivermectin.

中文翻译：

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在加纳、利比里亚和刚果民主共和国，单剂量莫昔克丁与伊维菌素治疗盘尾丝虫感染：一项随机、对照、双盲 3 期试验。

盘尾丝虫病是一种主要在撒哈拉以南非洲地区流行的寄生虫病，其发病率和社会经济影响推动了大规模的发病率和传播控制计划。每年以社区为导向的伊维菌素治疗已大大降低了患病率。消除需要加紧努力，包括更有效的治疗。我们比较了莫昔克丁和伊维菌素的寄生虫学疗效和安全性。