Bone disease contributes to relevant morbidity after solid organ transplantation. Vitamin D has a crucial role for bone metabolism. Activation of vitamin D depends on the endocrine function of both, liver and kidney. Our study assessed key markers of bone metabolism at time of transplantation and 6 months after transplantation among 70 kidney and 70 liver recipients. In 70 kidney recipients 25-OH vitamin D levels did not differ significantly between peri-transplant (median 32.5nmol/l) and 6 months post-transplant (median 41.9nmol/l; P = 0.272). Six months post-transplant median 1, 25-(OH)₂ vitamin D levels increased by >300% (from 9.1 to 36.5ng/l; P<0.001) and median intact parathyroid hormone levels decreased by 68.4% (from 208.7 to 66.0 ng/l; P<0.001). Median β-Crosslaps (CTx) and total procollagen type 1 amino-terminal propeptide (P1NP) decreased by 65.1% (from 1.32 to 0.46ng/ml; P<0.001) and 60.6% (from 158.2 to 62.3ng/ml; P<0.001), respectively. Kidney recipients with incident fractures had significantly lower levels of 1, 25-(OH)₂ vitamin D at time of transplantation and of intact parathyroid hormone 6 months post-transplant. Among 70 liver recipients, 25-OH vitamin D, 1, 25-(OH)₂ vitamin D and intact parathyroid hormone levels were not significantly altered between peri-transplant and 6 months post-transplant. Contrary to kidney recipients, median CTx increased by 60.0% (from 0.45 to 0.72 ng/ml; P = 0.002) and P1NP by 49.3% (from 84.0 to 125.4ng/ml; P = 0.001) in the longitudinal course. Assessed biomarkers didn’t differ between liver recipients with and without fractures. To conclude, the assessed panel of biomarkers proved highly dynamic after liver as well as kidney transplantation in the early post-transplant period. After kidney transplantation a significant gain in 1, 25-(OH)₂ vitamin D combined with a decline in iPTH, CTx and P1NP, whereas after liver transplantation an increase in CTx and P1NP were characteristic.

实体器官移植后，骨病会导致相关的发病率。维生素D对骨骼代谢具有至关重要的作用。维生素D的激活取决于肝脏和肾脏的内分泌功能。我们的研究评估了70位肾脏和70位肝脏接受者在移植时和移植后6个月骨代谢的关键指标。在70名肾脏接受者中，移植前后（中位数32.5nmol / l）和移植后6个月（中位数41.9nmol / l）之间的25-OH维生素D水平无显着差异（P = 0.272）。移植后六个月，维生素D的中位数1、25-（OH）₂升高了300％以上（从9.1降至36.5ng / l；P <0.001），而完整的甲状旁腺激素水平降低了68.4％（从208.7降低至66.0） ng / l; P<0.001）。中值β-交叉（CTx）和总胶原蛋白1型氨基末端前肽（P1NP）分别下降65.1％（从1.32下降至0.46ng / ml; P <0.001）和60.6％（从158.2下降至62.3ng / ml; P < 0.001）。发生骨折的肾脏接受者在移植时和移植后6个月时具有较低的1，25-（OH）₂维生素D水平和完整的甲状旁腺激素水平。在70位肝脏接受者中，移植前后和移植后6个月间25-OH维生素D，1、25-（OH）₂维生素D和完整的甲状旁腺激素水平没有显着改变。与肾脏接受者相反，CTx的中位数增加了60.0％（从0.45 ng / ml增至0.72 ng / ml；P= 0.002）和在纵向过程中P1NP降低49.3％（从84.0到125.4ng / ml; P = 0.001）。在有或没有骨折的肝接受者之间，评估的生物标志物没有差异。总而言之，经过评估的生物标志物组证明在移植后早期的肝脏和肾脏移植后具有很高的动态性。肾脏移植后，1，25-（OH）₂维生素D显着增加，而iPTH，CTx和P1NP下降，而肝脏移植后，CTx和P1NP升高是特征。