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Implicit learning deficit in children with Duchenne muscular dystrophy: Evidence for a cerebellar cognitive impairment?
PLOS ONE ( IF 2.9 ) Pub Date : 2018-01-16 , DOI: 10.1371/journal.pone.0191164
Stefano Vicari , Giorgia Piccini , Eugenio Mercuri , Roberta Battini , Daniela Chieffo , Sara Bulgheroni , Chiara Pecini , Simona Lucibello , Sara Lenzi , Federica Moriconi , Marika Pane , Adele D’Amico , Guja Astrea , Giovanni Baranello , Daria Riva , Giovanni Cioni , Paolo Alfieri

This study aimed at comparing implicit sequence learning in individuals affected by Duchenne Muscular Dystrophy without intellectual disability and age-matched typically developing children. A modified version of the Serial Reaction Time task was administered to 32 Duchenne children and 37 controls of comparable chronological age. The Duchenne group showed a reduced rate of implicit learning even if in the absence of global intellectual disability. This finding provides further evidence of the involvement of specific aspects of cognitive function in Duchenne muscular dystrophy and on its possible neurobiological substrate.



中文翻译:

杜兴氏肌营养不良症儿童的内隐学习障碍:小脑认知障碍的证据吗?

这项研究旨在比较受杜氏肌营养不良症影响而无智力障碍和年龄匹配的典型发育儿童的个体的内隐序列学习。修正版的“连续反应时间”任务被施用于32位Duchenne儿童和37位年龄相仿的对照。即使没有全球性智力障碍,杜兴大学的小组也表现出降低的内隐学习率。这一发现提供了进一步的证据,证明认知功能的特定方面参与了杜兴氏肌营养不良症及其可能的神经生物学底物。

更新日期:2018-01-17
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