Zika virus (ZIKV) infection during pregnancy leads to an increased risk of fetal growth restriction and fetal central nervous system malformations, which are outcomes broadly referred to as the Congenital Zika Syndrome (CZS). Here we infect pregnant rhesus macaques and investigate the impact of persistent ZIKV infection on uteroplacental pathology, blood flow, and fetal growth and development. Despite seemingly normal fetal growth and persistent fetal-placenta-maternal infection, advanced non-invasive in vivo imaging studies reveal dramatic effects on placental oxygen reserve accompanied by significantly decreased oxygen permeability of the placental villi. The observation of abnormal oxygen transport within the placenta appears to be a consequence of uterine vasculitis and placental villous damage in ZIKV cases. In addition, we demonstrate a robust maternal-placental-fetal inflammatory response following ZIKV infection. This animal model reveals a potential relationship between ZIKV infection and uteroplacental pathology that appears to affect oxygen delivery to the fetus during development.

中文翻译：

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孕妇恒河猴中的寨卡病毒感染会导致胎盘功能障碍和免疫病理。

怀孕期间感染寨卡病毒（ZIKV）会导致胎儿生长受限和胎儿中枢神经系统畸形的风险增加，这些结果被广泛称为先天性寨卡综合症（CZS）。在这里，我们感染了猕猴，并调查了持续ZIKV感染对子宫胎盘病理学，血流和胎儿生长发育的影响。尽管看似正常的胎儿生长和持续的胎儿-胎盘-母亲感染，但先进的非侵入性体内成像研究显示出对胎盘氧储备的显着影响，并伴随着胎盘绒毛的氧渗透性显着降低。在ZIKV病例中，观察到胎盘内氧气传输异常似乎是子宫血管炎和胎盘绒毛损害的结果。此外，我们证明ZIKV感染后母体-胎盘-胎儿的炎症反应强烈。这种动物模型揭示了ZIKV感染与子宫胎盘病理之间的潜在关系，这种关系似乎会影响发育过程中向胎儿的氧气输送。