Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels.,Nature Communications

当前位置： X-MOL 学术 › Nat. Commun. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels.
Nature Communications ( IF 14.7 ) Pub Date : 2018-01-17 , DOI: 10.1038/s41467-017-02662-2
Xia Jiang _{1,

2} , Paul F O'Reilly ₃ , Hugues Aschard _{1,

4} , Yi-Hsiang Hsu _{5,

6,

7} , J Brent Richards ₈ , Josée Dupuis _{9,

10} , Erik Ingelsson _{11,

12} , David Karasik ₅ , Stefan Pilz ₁₃ , Diane Berry ₁₄ , Bryan Kestenbaum ₁₅ , Jusheng Zheng ₁₆ , Jianan Luan ₁₆ , Eleni Sofianopoulou ₁₇ , Elizabeth A Streeten ₁₈ , Demetrius Albanes ₁₉ , Pamela L Lutsey ₂₀ , Lu Yao ₂₀ , Weihong Tang ₂₀ , Michael J Econs ₂₁ , Henri Wallaschofski _{22,

23} , Henry Völzke _{23,

24} , Ang Zhou ₂₅ , Chris Power ₁₄ , Mark I McCarthy _{26,

27,

28} , Erin D Michos _{29,

30} , Eric Boerwinkle ₃₁ , Stephanie J Weinstein ₁₉ , Neal D Freedman ₁₉ , Wen-Yi Huang ₃₂ , Natasja M Van Schoor ₃₃ , Nathalie van der Velde _{34,

35} , Lisette C P G M de Groot ₃₆ , Anke Enneman ₃₄ , L Adrienne Cupples _{9,

10} , Sarah L Booth ₃₇ , Ramachandran S Vasan ₁₀ , Ching-Ti Liu ₉ , Yanhua Zhou ₉ , Samuli Ripatti ₃₈ , Claes Ohlsson ₃₉ , Liesbeth Vandenput ₃₉ , Mattias Lorentzon ₄₀ , Johan G Eriksson _{41,

42} , M Kyla Shea ₃₇ , Denise K Houston ₄₃ , Stephen B Kritchevsky ₄₃ , Yongmei Liu ₄₄ , Kurt K Lohman ₄₅ , Luigi Ferrucci ₄₆ , Munro Peacock ₂₁ , Christian Gieger ₄₇ , Marian Beekman ₄₈ , Eline Slagboom ₄₈ , Joris Deelen _{48,

49} , Diana van Heemst ₅₀ , Marcus E Kleber ₅₁ , Winfried März _{51,

52,

53} , Ian H de Boer ₅₄ , Alexis C Wood ₅₅ , Jerome I Rotter ₅₆ , Stephen S Rich _{57,

58} , Cassianne Robinson-Cohen ₅₉ , Martin den Heijer ₆₀ , Marjo-Riitta Jarvelin _{61,

62,

63,

64} , Alana Cavadino _{14,

65} , Peter K Joshi ₆₆ , James F Wilson _{66,

67} , Caroline Hayward ₆₇ , Lars Lind ₁₂ , Karl Michaëlsson ₆₈ , Stella Trompet _{50,

69} , M Carola Zillikens ₆₀ , Andre G Uitterlinden _{34,

60} , Fernando Rivadeneira _{34,

60} , Linda Broer ₆₀ , Lina Zgaga ₇₀ , Harry Campbell _{66,

71} , Evropi Theodoratou _{66,

71} , Susan M Farrington ₇₁ , Maria Timofeeva ₇₁ , Malcolm G Dunlop ₇₁ , Ana M Valdes _{72,

73} , Emmi Tikkanen ₇₄ , Terho Lehtimäki _{75,

76} , Leo-Pekka Lyytikäinen _{75,

76} , Mika Kähönen _{77,

78} , Olli T Raitakari _{79,

80} , Vera Mikkilä ₈₁ , M Arfan Ikram ₃₄ , Naveed Sattar ₈₂ , J Wouter Jukema _{69,

83} , Nicholas J Wareham ₁₆ , Claudia Langenberg ₁₆ , Nita G Forouhi ₁₆ , Thomas E Gundersen ₈₄ , Kay-Tee Khaw ₁₇ , Adam S Butterworth ₁₇ , John Danesh _{17,

85} , Timothy Spector ₇₂ , Thomas J Wang ₈₆ , Elina Hyppönen _{14,

25} , Peter Kraft ₁ , Douglas P Kiel _{5,

6,

7}

Affiliation

Program in Genetic Epidemiology and Statistical Genetics. Department of Epidemiology, Harvard T.H.Chan School of Public Health, 677 Huntington Avenue, Boston, 02115, MA, USA.
Unit of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Nobels vagen 13, Stockholm, 17177, Sweden.
Department of Social Genetic & Developmental Psychiatry, King's College London, Institute of Psychiatry, De Crespigny Park, London, SE5 8AF, UK.
Centre de Bioinformatique, Biostatistique et Biologie Intégrative (C3BI), Institut Pasteur, Paris, 75724, France.
Institute for Aging Research, Hebrew SeniorLife, 1200 Centre Street, Boston, MA, 02131, USA.
Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, 02115, USA.
Broad Institute of Harvard and Massachusetts Institute of Technology, Boston, MA, 02142, USA.
Departments of Medicine, Human Genetics, Epidemiology and Biostatistics, 3755 Côte Ste-Catherine Road, Suite H-413 Montréal, Québec, H3T 1E2, Canada.
Department of Biostatistics, Boston University School of Public Health, Crosstown Center. 801 Massachusetts Avenue 3rd Floor, Boston, MA, 02118, USA.
Framingham Heart Study, 73 Mt. Wayte Avenue, Framingham, MA, 01702, USA.
Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine Stanford, Stanford, CA, 94305, USA.
Department of Medical Sciences, Uppsala University, 751 85, Uppsala, Sweden.
Department of Internal Medicine, Division of Endocrinology and Diabetology, Medical University of Graz, Auenbruggerplatz 15, 8036, Graz, Austria.
Population, Policy and Practice, University College London, Great Ormond Street, Institute of Child Health, London, WC1E 6BT, UK.
Kidney Research Institute, Division of Nephrology, 325 Ninth Avenue, Seattle, WA, 98104, USA.
MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.
Department of Public Health & Primary Care, University of Cambridge, Strangeways Research Laboratory, Wort's Causeway, Cambridge, CB1 8RN, UK.
Genetics and Personalized Medicine Program, University of Maryland School of Medicine, Howard Hall Room 567, Baltimore, MD, 21201, USA.
Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, 9609 Medical Center Drive, Bethesda, MD, 20892, USA.
Division of Epidemiology & Community Health, School of Public Health, University of Minnesota, 1300S 2nd Street, Suite 300, Minneapolis, MN, 55454, USA.
Department of Medicine, Indiana University, Endocrinology, 1120W Michigan Street, Indianapolis, IN, 46202-5124, USA.
Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, 17489, Greifswald, Germany.
DZHK (German Centre for Cardiovascular Research), Partner Site, Greifswald, 13316, Berlin, Germany.
Institut für Community Medicine, SHIP/Klinisch-Epidemiologische Forschung, Universitätsmedizin Greifswald, Walther-Rathenau-Str. 48, 17475, Greifswald, Germany.
Centre for Population Health Research, Sansom Institute for Health Research, University of South Australia, Adelaide, 5001, SA, Australia.
Oxford Centre for Diabetes Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Old Road, Headington, Oxford, OX3 7LJ, UK.
Wellcome Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, Oxford, OX3 7BN, UK.
Oxford NIHR Biomedical Research Centre, Churchill Hospital, Old Road, Headington, Oxford, OX3 7LJ, UK.
Division of Cardiology, Ciccarone Center for the Prevention of Heart Disease, Johns Hopkins School of Medicine, Baltimore, MD, 21287, USA.
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 21205, USA.
Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.
Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, 9609 Medical Center Drive, Bethesda, MD, 20892, USA.
Department of Epidemiology and Biostatistics, Amsterdam Public Health Research Institute, VU University Medical Center, De Boelelaan 1089a, 1081 HV, Amsterdam, The Netherlands.
Erasmus MC Department of Epidemiology, Postbus 2040, 3000CA, Rotterdam, The Netherlands.
AMC, Internal Medicine, Geriatrics Department, PO Box 22700, 1100 DE, Amsterdam, The Netherlands.
Department of Human Nutrition, Wageningen University, PO-box 17, 6700 AA, Wageningen, The Netherlands.
Vitamin K Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA, 02111, USA.
Statistical and Translational Genetics, University of Helsinki, Tukholmankatu 8, Building, Biomedicum, Helsinki 2U, Finland.
Department of Internal Medicine and Clinical Nutrition, University of Gothenburg, Vita Stråket 11, Gothenburg, 41345, Sweden.
Department of Geriatric Medicine, University of Gothenburg and Sahlgrenska University Hospital, Mölndal, 43180, Sweden.
Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, University of Helsinki, P.O. Box 20, Tukholmankatu, 8 B 00014, Finland.
Folkhälsan Research Center, University of Helsinki, Helsinki, PO Box 2000014, Finland.
Sticht Center for Healthy Aging and Alzheimer's Prevention, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC, 27157, USA.
Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest School of Medicine, Medical Center Blvd, Winston-Salem, NC, 27157, USA.
Department of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest School of Medicine, Medical Center Blvd, Winston-Salem, NC, 27157, USA.
Longitudinal Studies Section, Intramural Research Program of the National Institute on Aging, NIH, Baltimore, MD, 21225, USA.
German Research Center for Environmental Health, Molecular Epidemiology, AME, Ingolstädter Landstr 1, D-85764, Neuherberg, Germany.
Molecular Epidemiology, Leiden University Medical Center, Einthovenweg 20, 2333 ZC, Leiden, The Netherlands.
Max Planck Institute for Biology of Ageing, Joseph-Stelzmann-Str. 9b, D-50931, Köln (Cologne), Germany.
Gerontology and Geriatrics, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands.
Vth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer1, 68167, Mannheim, Germany.
Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Auenbruggerplatz 15, 8036, Graz, Graz, Austria.
SYNLAB Holding Deutschland GmbH, Gubener Straße 39, 86156, Augsburg, Germany.
Division of Nephrology and Kidney Research Institute, University of Washington, 325 ninth Avenue, Washington, DC, 98104, USA.
USDA/ARS Children's Nutrition Research Center, 1100 Bates Avenue, Houston, TX, 77071, USA.
Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, 90502, USA.
Department of Public Health Sciences, University of Virginia, Charlottesville, VA, 22908, USA.
Center for Public Health Genomics, University of Virginia, Charlottesville, VA, 22908, USA.
Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, 1161 21st Ave S., Nashville, TN, 37232, USA.
Erasmus MC Department of Internal Medicine, Postbus 2040, 3000CA, Rotterdam, The Netherlands.
Epidemiology and Biostatistics School of Public Health, Imperial College London, 156 Norfolk Place, St. Mary's Campus, London, UK W2 1PG, UK.
Center for Life Course Health Research, Faculty of Medicine, University of Oulu, 90014, Oulu, Finland.
Biocenter Oulu, University of Oulu, P.O. Box 5000, Aapistie 5A, FI-90014, Finland.
Unit of Primary Care, Oulu University Hospital, Kajaanintie 50, P.O. Box 20, FI-90220 Oulu, 90029 OYS, Finland.
Centre for Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK.
Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, UK.
MRC Human Genetics Unit, MRC Institute of Genetics & Molecular Medicine, the University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK.
Department of Surgical Sciences, Uppsala University, Dag Hammarskjöldsv 14 B, Uppsala Science Park, 751 85, Uppsala, Sweden.
Department of Cardiology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, Netherlands.
Department of Public Health and Primary Care, Institute of Population Health, Trinity College Dublin, University of Dublin, Dublin 24, D02 PN40, Ireland.
Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK.
The Department of Twin Research & Genetic Epidemiology, King's College London, St Thomas' Campus, Westminster Bridge Road, London, SE1 7EH, UK.
School of Medicine, University of Nottingham, City Hospital, Hucknall Rd, Nottingham, NG5 1PB, UK.
FIMM-Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, P.O. Box 20, FI-00014, Finland.
Department of Clinical Chemistry, Fimlab Laboratories, Tampere, 33520, Finland.
Department of Clinical Chemistry, Finnish Cardiovascular Research Center Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, 33014, Finland.
Department of Clinical Physiology, Tampere University Hospital, Tampere, 33521, Finland.
Department of Clinical Physiology, Finnish Cardiovascular Research Center Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, 33014, Finland.
Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, 20521, Finland.
Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, 20014, Finland.
Science Adviser at Academy of Finland, Hakaniemenranta 6, PO Box 131, FI-00531, Helsinki, Finland.
BHF Glasgow Cardiovascular Research Centre, Faculty of Medicine, University Avenue, Glasgow, G12 8QQ, UK.
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands.
Vitas AS, Gaustadaleen 21, N-0349, Oslo, Norway.
Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.
Division of Cardiovascular Medicine, Vanderbilt Heart and Vascular Institute, 2220 Pierce Avenue 383 Preston Research Building, Nashville, TN, 37232-6300, USA.

Vitamin D is a steroid hormone precursor that is associated with a range of human traits and diseases. Previous GWAS of serum 25-hydroxyvitamin D concentrations have identified four genome-wide significant loci (GC, NADSYN1/DHCR7, CYP2R1, CYP24A1). In this study, we expand the previous SUNLIGHT Consortium GWAS discovery sample size from 16,125 to 79,366 (all European descent). This larger GWAS yields two additional loci harboring genome-wide significant variants (P = 4.7×10^-9 at rs8018720 in SEC23A, and P = 1.9×10^-14 at rs10745742 in AMDHD1). The overall estimate of heritability of 25-hydroxyvitamin D serum concentrations attributable to GWAS common SNPs is 7.5%, with statistically significant loci explaining 38% of this total. Further investigation identifies signal enrichment in immune and hematopoietic tissues, and clustering with autoimmune diseases in cell-type-specific analysis. Larger studies are required to identify additional common SNPs, and to explore the role of rare or structural variants and gene-gene interactions in the heritability of circulating 25-hydroxyvitamin D levels.

中文翻译：

对 79,366 名欧洲血统个体进行的全基因组关联研究揭示了 25-羟基维生素 D 水平的遗传结构。

维生素 D 是一种类固醇激素前体，与一系列人类特征和疾病有关。先前对血清 25-羟基维生素 D 浓度的 GWAS 已鉴定出四个全基因组显着位点（GC、NADSYN1/DHCR7、CYP2R1、CYP24A1）。在这项研究中，我们将之前 SUNLIGHT Consortium GWAS 发现的样本量从 16,125 扩大到 79,366（均为欧洲血统）。这个更大的 GWAS 产生了两个额外的基因座，其中包含全基因组显着变异（SEC23A 中 rs8018720 处的 P = 4.7×10 ^-9 ，AMDHD1 中 rs10745742 处的 P = 1.9×10 ^-14 ）。 GWAS 常见 SNP 引起的 25-羟基维生素 D 血清浓度遗传力的总体估计为 7.5%，统计上显着的位点解释了总数的 38%。进一步的研究确定了免疫和造血组织中的信号富集，以及细胞类型特异性分析中与自身免疫性疾病的聚类。需要更大规模的研究来确定其他常见的 SNP，并探索罕见或结构变异以及基因间相互作用在循环 25-羟基维生素 D 水平遗传性中的作用。

更新日期：2018-01-17

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11