Left ventricular mass index (LVMI) increase has been described in hypertension (HTN), but less is known about its association with type 2 diabetes (T2DM). As these conditions frequently co-exist, we investigated the association of T2DM, HTN and both with echocardiographic parameters, and hypothesized that patients with both had highest LVMI, followed by patients with only T2DM or HTN. Study population included 101 T2DM patients, 62 patients with HTN and no T2DM, and 76 patients with T2DM and HTN, excluded for ischemic heart disease. Demographic and clinical data, biochemical measurements, stress echocardiography, transthoracic 2D Doppler and tissue Doppler echocardiography were performed. Multivariable logistic regression was used to determine the independent association with T2DM. Linear regression models and Pearson's correlation were used to assess the correlations between LVMI and other parameters. Patients with only T2DM had significantly greater LVMI (84.9 ± 20.3 g/m²) compared to patients with T2DM and HTN (77.9 ± 16 g/m²) and only HTN (69.8 ± 12.4 g/m²). In multivariate logistic regression analysis, T2DM was associated with LVMI (OR 1.033, 95%CI 1.003-1.065, p = 0.029). A positive correlation of LVMI was found with fasting glucose (p < 0.001) and HbA1c (p = 0.0003). Increased LVMI could be a potential, pre-symptomatic marker of myocardial structural change in T2DM.

中文翻译：

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没有缺血性心脏病的2型糖尿病患者的左心室质量指数增加。

高血压（HTN）中已有左心室质量指数（LVMI）升高的报道，但其与2型糖尿病（T2DM）的关联还鲜为人知。由于这些情况经常并存，因此我们调查了T2DM，HTN以及两者与超声心动图参数之间的关系，并假设这两种患者的LVMI最高，其次是仅T2DM或HTN的患者。研究人群包括101例T2DM患者，62例HTN且无T2DM的患者以及76例T2DM和HTN的患者，这些患者因缺血性心脏病而被排除在外。进行了人口统计学和临床​​数据，生化测量，应力超声心动图，经胸2D多普勒和组织多普勒超声心动图。多变量logistic回归用于确定与T2DM的独立关联。线性回归模型和Pearson' 的相关性用于评估LVMI与其他参数之间的相关性。仅患有T2DM的患者的LVMI明显更高（84.9±20.3 g / m²）与T2DM和HTN（77.9±16 g / m ²）而仅HTN（69.8±12.4 g / m ²）的患者相比。在多因素logistic回归分析中，T2DM与LVMI相关（OR 1.033，95％CI 1.003-1.065，p = 0.029）。LVMI与空腹血糖（p <0.001）和HbA1c（p = 0.0003）呈正相关。LVMI升高可能是T2DM心肌结构变化的潜在症状征兆。