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Dealloyed Intra-Nanogap Particles with Highly Robust, Quantifiable Surface-Enhanced Raman Scattering Signals for Biosensing and Bioimaging Applications
ACS Central Science ( IF 12.7 ) Pub Date : 2018-01-17 00:00:00 , DOI: 10.1021/acscentsci.7b00584
Minho Kim 1 , Sung Min Ko 1 , Jae-Myoung Kim 1 , Jiwoong Son 1 , Chungyeon Lee 1 , Won-Kyu Rhim 1 , Jwa-Min Nam 1
Affiliation  

Uniformly controlling a large number of metal nanostructures with a plasmonically enhanced signal to generate quantitative optical signals and the widespread use of these structures for surface-enhanced Raman scattering (SERS)-based biosensing and bioimaging applications are of paramount importance but are extremely challenging. Here, we report a highly controllable, facile selective-interdiffusive dealloying chemistry for synthesizing the dealloyed intra-nanogap particles (DIPs) with a ∼2 nm intragap in a high yield (∼95%) without the need for an interlayer. The SERS signals from DIPs are highly quantitative and polarization-independent with polarized laser sources. Remarkably, all the analyzed particles displayed the SERS enhancement factors (EFs) of ≥1.1 × 108 with a very narrow distribution of EFs. Finally, we show that DIPs can be used as ultrasensitive SERS-based DNA detection probes for detecting 10 aM to 1 pM target concentrations and highly robust, quantitative real-time cell imaging probes for long-term imaging with low laser power and short exposure time.

中文翻译:


具有高度稳健、可量化的表面增强拉曼散射信号的脱合金纳米间隙颗粒,适用于生物传感和生物成像应用



利用等离子体增强信号均匀控制大量金属纳米结构以产生定量光信号,并将这些结构广泛用于基于表面增强拉曼散射(SERS)的生物传感和生物成像应用至关重要,但也极具挑战性。在这里,我们报告了一种高度可控、简便的选择性相互扩散脱合金化学,用于以高产率(~95%)合成脱合金纳米间隙内颗粒(DIP),其内间隙为~2 nm(~95%)。来自 DIP 的 SERS 信号是高度定量的,并且与偏振激光源的偏振无关。值得注意的是,所有分析的颗粒都显示出 ≥1.1 × 10 8的 SERS 增强因子 (EF),并且 EF 的分布非常窄。最后,我们证明 DIP 可用作超灵敏的基于 SERS 的 DNA 检测探针,用于检测 10 aM 至 1 pM 的目标浓度,以及高度稳健的定量实时细胞成像探针,用于低激光功率和短曝光时间的长期成像。
更新日期:2018-01-17
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