Prenylated 2-Phenoxychromones and Flavonoids from Epimedium brevicornum and Revised Structures of Epimedonins A and B,Journal of Natural Products

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Prenylated 2-Phenoxychromones and Flavonoids from Epimedium brevicornum and Revised Structures of Epimedonins A and B
Journal of Natural Products ( IF 3.3 ) Pub Date : 2018-01-17 00:00:00 , DOI: 10.1021/acs.jnatprod.7b00514
Fu-Cai Ren ₁ , Xian-Jun Jiang ₁ , Shi-Zhen Wen ₁ , Li-Xia Wang ₁ , Xiang-Mei Li ₁ , Fei Wang ₁

Affiliation

Six hitherto unknown prenylated 2-phenoxychromones, epimedonin G (1), 7-O-methylepimedonin G (2), and epimedonins H–K (3–6), and two new prenylflavonoids, epimedonin L (7) and 3″-O-desmethylspinorhamnoside (8), were isolated from an ethanol extract of the aerial parts of Epimedium brevicornum. Their structures were established on the basis of spectroscopic data interpretation. Compound 7 exhibited cytotoxic activity when evaluated against four human cancer cell lines (HL-60, A-549, MCF-7, and SW-480), with IC₅₀ values of <10 μM. In addition, the structures of epimedonins A and B (9a, 10a), recently isolated from E. koreanum, were corrected by reanalysis of the published NMR data.

中文翻译：

淫羊med的异戊二烯化2-苯氧基色酮和类黄酮以及淫羊on甙A和B的修饰结构

六个迄今未知的异戊二烯化2-苯氧基色酮，淫羊on素G（1），7- O-甲基表二烯酮G（2）和淫羊on素H–K（3 – 6），以及两个新的异戊二烯类黄酮，淫羊on素L（7）和3″ -O -desmethylspinorhamnoside（8），是从淫羊Epi淫羊aerial（Epimedium brevicornum）地上部分的乙醇提取物中分离得到的。它们的结构是在光谱数据解释的基础上建立的。当针对具有IC _50的四种人类癌细胞系（HL-60，A-549，MCF-7和SW-480）进行评估时，化合物7表现出细胞毒性活性值<10μM。此外，通过重新分析已发表的NMR数据，对最近从大肠埃希氏菌中分离出的Epimedonins A和B（9a，10a）的结构进行了校正。

更新日期：2018-01-17

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