Double‐Emulsion‐Templated Anisotropic Microcapsules for pH‐Triggered Release,Advanced Materials Interfaces

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Double‐Emulsion‐Templated Anisotropic Microcapsules for pH‐Triggered Release
Advanced Materials Interfaces ( IF 4.3 ) Pub Date : 2018-01-17 , DOI: 10.1002/admi.201701472
Bomi Kim ₁ , Sangmin Lee ₁ , Shin-Hyun Kim ₁

Affiliation

Biocompatible microcapsules with a function of pH‐triggered release are promising for the site‐specific release of bio‐actives in the human body. In this work, smart microcapsules with three distinct configurations of membranes are produced to control the rate of pH‐triggered release. The microcapsules are prepared with a template of water‐in‐oil‐in‐water double‐emulsion drops. The oil shells of drops contain two polymers dissolved in an organic solvent: one is a biodegradable polymer selected from poly(lactic acid), poly(lactic‐co‐glycolic acid), and polycaprolactone, and the other is a pH‐responsive cationic polymer. Upon the depletion of organic solvent, two polymers confined in the shell undergo phase separation and double‐emulsion drops transform to microcapsules with the solid membrane. Three different configurations of the membranes − spherical, snowman‐like, and eyeball‐like structures − are exclusively produced according to the selection of biodegradable polymers. Although all the microcapsules release hydrophilic encapsulant loaded in the core when they are subjected to a weakly acidic condition, the release kinetics strongly depends on the configuration of the membrane. Larger surface coverage and thinner membrane of pH‐responsive domains result in faster release.

中文翻译：

pH触发释放的双乳液模板各向异性微胶囊

具有pH触发释放功能的生物相容性微胶囊有望在人体中实现特定位置的生物活性物质释放。在这项工作中，生产了具有三种截然不同的膜结构的智能微胶囊，以控制pH触发的释放速率。用水包油包水型双乳液滴剂模板制备微胶囊。液滴的油壳含有溶解在有机溶剂中的两种聚合物：一种是由聚（乳酸）中选择的生物可降解聚合物，聚（乳酸-共乙醇酸）和聚己内酯，另一个是对pH敏感的阳离子聚合物。随着有机溶剂的消耗，限制在壳中的两种聚合物会发生相分离，双乳液滴剂会转化为带有固体膜的微胶囊。膜的三种不同配置-球形，雪人形和眼球状-根据选择的可生物降解聚合物专门生产。尽管所有微囊在弱酸性条件下都会释放负载在核中的亲水性密封剂，但释放动力学在很大程度上取决于膜的结构。pH响应域的更大的表面覆盖范围和更薄的膜可导致更快的释放。

更新日期：2018-01-17

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