Enantioselective Synthesis of Aminodiols by Sequential Rhodium‐Catalysed Oxyamination/Kinetic Resolution: Expanding the Substrate Scope of Amidine‐Based Catalysis,Chemistry - A European Journal

当前位置： X-MOL 学术 › Chem. Eur. J. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Enantioselective Synthesis of Aminodiols by Sequential Rhodium‐Catalysed Oxyamination/Kinetic Resolution: Expanding the Substrate Scope of Amidine‐Based Catalysis
Chemistry - A European Journal ( IF 3.9 ) Pub Date : 2018-02-28 , DOI: 10.1002/chem.201705670
Joan Guasch ₁ , Irene Giménez‐Nueno ₁ , Ignacio Funes‐Ardoiz ₂ , Miguel Bernús ₁ , M. Isabel Matheu ₁ , Feliu Maseras _{2,

3} , Sergio Castillón ₁ , Yolanda Díaz ₁

Affiliation

Regio‐ and stereoselective oxyamination of dienes through a tandem rhodium‐catalysed aziridination–nucleophilic opening affords racemic oxazolidinone derivatives, which undergo a kinetic resolution acylation process with amidine‐based catalysts (ABCs) to achieve s values of up to 117. This protocol was applied to the enantioselective synthesis of sphingosine.

中文翻译：

连续铑催化的氧化/动力学拆分对氨基二醇的对映选择性合成：扩大了of基催化的底物范围

通过串联铑催化的叠氮化-亲核开口进行二烯的区域和立体选择性氧化胺化反应，得到外消旋的恶唑烷酮衍生物，其与with基催化剂（ABCs）进行动力学拆分酰化反应，可得到高达117的s值。采用了该协议对鞘氨醇的对映选择性合成。

更新日期：2018-02-28

点击分享查看原文

点击收藏

阅读更多本刊最新论文