Increasing numbers of disulfide linkage‐employing polymeric drug carriers that utilize the reversible peculiarity of this unique covalent bond have been reported. The reduction‐sensitive disulfide bond is usually employed as a linkage between hydrophilic and hydrophobic polymers, polymers and drugs, or as cross‐linkers in polymeric drug carriers. These polymeric drug carriers are designed to exploit the significant redox potential difference between the reducing intracellular environments and relatively oxidizing extracellular spaces. In addition, these drug carriers can release a considerable amount of anticancer drug in response to the reducing environment when they reach tumor tissues, effectively improving antitumor efficacy. This review focuses on various disulfide linkage‐employing polymeric drug carriers. Important redox thiol pools, including GSH/GSSG, Cys/CySS, and Trx1, as well as redox environments in mammals, will be introduced.

中文翻译：

---

基于二硫键的聚合物药物载体，用于哺乳动物的癌症化疗和相关的氧化还原环境

据报道，利用这种独特的共价键的可逆特性的使用二硫键的聚合物药物载体越来越多。还原敏感性二硫键通常用作亲水性和疏水性聚合物，聚合物和药物之间的连接，或用作聚合物药物载体中的交联剂。这些聚合的药物载体被设计为利用减少的细胞内环境和相对氧化的细胞外空间之间的显着氧化还原电势差。另外，这些药物载体在到达肿瘤组织时可以响应于还原环境而释放出大量的抗癌药物，从而有效地提高了抗肿瘤功效。这篇综述着重于各种采用二硫键的聚合物药物载体。重要的氧化还原硫醇池，