Expanding the chemical diversity of TNA with tUTP derivatives that are substrates for a TNA polymerase,Chemical Communications

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Expanding the chemical diversity of TNA with tUTP derivatives that are substrates for a TNA polymerase
Chemical Communications ( IF 4.3 ) Pub Date : 2018-01-17 00:00:00 , DOI: 10.1039/c7cc09130c
Hui Mei _{1,

2,

3,

4} , John C. Chaput _{1,

2,

3,

4}

Affiliation

Expanding the chemical diversity of threose nucleic acid (TNA) beyond the natural bases would enable the development of TNA polymers with enhanced physicochemical properties. Here, we describe a versatile approach for increasing the chemical diversity of TNA using 5-alkynyl-modified α-L-threofuranosyl uridine triphosphates that are substrates for a TNA polymerase.

中文翻译：

使用tUTP衍生物扩展TNA的化学多样性，tUTP衍生物是TNA聚合酶的底物

将苏糖核酸（TNA）的化学多样性扩展到天然碱基以外，将能够开发具有增强的物理化学性质的TNA聚合物。在这里，我们描述了一种通用的方法，可以使用TNA聚合酶的底物5-炔基修饰的α- L-苏呋喃糖基尿苷三磷酸来增加TNA的化学多样性。

更新日期：2018-01-31

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