Pretargeted Immuno-PET Based on Bioorthogonal Chemistry for Imaging EGFR Positive Colorectal Cancer,Bioconjugate Chemistry

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Pretargeted Immuno-PET Based on Bioorthogonal Chemistry for Imaging EGFR Positive Colorectal Cancer
Bioconjugate Chemistry ( IF 4.0 ) Pub Date : 2018-01-18 00:00:00 , DOI: 10.1021/acs.bioconjchem.8b00023
Xudong Shi ₁ , Kai Gao ₁ , Hao Huang ₁ , Ran Gao ₁

Affiliation

Pretargeted immuno-PET imaging based on the bioorthogonal chemistry between ¹⁸F-labeled Reppe anhydride derivatives and tetrazine conjugates of the EGFR-specific monoclonal antibodies cetuximab and panitumumab was performed. This pretargeting approach yielded high target-to-nontarget ratios. Furthermore, due to the fast clearance rate of the PET probe, the overall radiation burden to nontarget tissues was also substantially decreased.

中文翻译：

基于生物正交化学的预靶向Immuno-PET对EGFR阳性结直肠癌的成像

基于¹⁸ F标记的Reppe酸酐衍生物与EGFR特异性单克隆抗体西妥昔单抗和帕尼单抗的四嗪偶联物之间的生物正交化学，进行了预靶向的免疫PET成像。这种预先确定目标的方法产生了很高的目标与非目标比率。此外，由于PET探针的快速清除率，对非目标组织的总体辐射负担也大大降低了。

更新日期：2018-01-18

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