Phyllanthus emblica L. fruit contains abundant bioactive components and exhibits a variety of biological activities. In this study, the hepatoprotective effect of water extract of P. emblica (WEPE) on nonalcoholic steatohepatitis (NASH) was evaluated. C57BL/6 mice were fed methionine and choline-deficiency diet (MCD diet) for 4 or 8 weeks to induce NASH. Results showed that administration of WEPE could significantly reduce serum AST and ALT as compared to MCD diet-alone group. Administration of WEPE could significantly decrease lipid peroxidation and CYP2E1 mRNA expression, and elevate the antioxidant activities in mice livers. In addition, administration of WEPE after 8 weeks could significantly decrease the mRNA expressions of TNF-α and IL-1β in mice livers, but have less improving effect of hepatic steatosis and mononuclear cell infiltration. Taken together, MCD diet might cause serious hepatic steatosis and mild inflammation in mice livers, but administration of WEPE could ameliorate the rapid progression of NASH.

中文翻译：

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余甘子果实对蛋氨酸和胆碱缺乏饮食诱导的非酒精性脂肪性肝炎的影响

Phyllanthus emblica L. 果实含有丰富的生物活性成分，表现出多种生物活性。在这项研究中，评估了余甘子水提取物 (WEPE) 对非酒精性脂肪性肝炎 (NASH) 的保肝作用。给 C57BL/6 小鼠喂食蛋氨酸和胆碱缺乏饮食（MCD 饮食）4 或 8 周以诱导 NASH。结果表明，与单独使用MCD饮食组相比，给予WEPE可显着降低血清AST和ALT。给予WEPE可显着降低脂质过氧化和CYP2E1 mRNA表达，并提高小鼠肝脏的抗氧化活性。此外，8周后给予WEPE可显着降低小鼠肝脏中TNF-α和IL-1β的mRNA表达，但对肝脏脂肪变性和单核细胞浸润的改善作用较小。