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Synthesis of 2,5-disubstituted 1,3,4-oxadiazoles by visible-light-mediated decarboxylation–cyclization of hydrazides and diketones
Tetrahedron Letters ( IF 1.5 ) Pub Date : 2018-01-16 , DOI: 10.1016/j.tetlet.2018.01.037
Pinhui Diao , Yanqin Ge , Wenpei zhang , Chen Xu , Nannan Zhang , Cheng Guo

A visible-light-induced synthesis of 2,5-disubstituted 1,3,4-oxadiazoles from simple diketones and hydrazides with the assistant of the photocatalyst eosin Y catalyzed decarboxylation and cyclization under mild conditions has been discovered. The reaction tolerates a wide range of functional groups and gives a variety of valuable 1,3,4-oxadiazoles in moderate to good yields. Finally, a plausible reaction mechanism was proposed.



中文翻译:

可见光介导的酰肼和二酮的脱羧环化反应合成2,5-二取代的1,3,4-恶二唑

发现了在光催化条件下,由简单的二酮和酰肼在光催化曙红Y的催化下可见光诱导的2,5-二取代的1,3,4-恶二唑的合成。该反应可耐受各种官能团,并以中等至良好的收率得到各种有价值的1,3,4-恶二唑。最后,提出了合理的反应机理。

更新日期:2018-01-16
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