Smart soaps: stimulus responsive soap–hydrogel bead composites for controlled dissolution and release of actives†,Materials Chemistry Frontiers

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Smart soaps: stimulus responsive soap–hydrogel bead composites for controlled dissolution and release of actives†
Materials Chemistry Frontiers ( IF 6.0 ) Pub Date : 2018-01-16 00:00:00 , DOI: 10.1039/c7qm00556c
Benjamin R. Thompson _{1,

2,

3,

4} , Marius Rutkevičius _{1,

2,

3,

4} , Tommy S. Horozov _{1,

2,

3,

4} , Simeon D. Stoyanov _{5,

6,

7,

8,

9} , Vesselin N. Paunov _{1,

2,

3,

4}

Affiliation

We designed pressure responsive soap–hydrogel bead composites by incorporating agar hydrogel beads of different size distributions within a molten soap matrix at various volume fractions. Upon cooling, the combined suspension of hydrogel beads into the molten soap was set into a composite of soap matrix. We demonstrate pressure driven syneresis of water from the soap–hydrogel bead composites upon compression. This allowed a release of active components embedded in the hydrogel beads upon application of pressure on these “smart” soap composites. We found that the dissolution rate of these composites generally increases with the volume percentage of hydrogel beads. We achieved a composite dissolution rate approximately 2.8 times higher than the soap control sample without hydrogel beads. However, the composite dissolution rate was independent of the size of the embedded hydrogel beads. We studied the release rates of active components encapsulated within the hydrogel beads used to prepare the composites. It was found that the release rate can be controlled in three different ways: varying the hydrogel beads size, using different concentrations of the gelling polymer used to make the hydrogel and also by co-encapsulating an oppositely charged polyelectrolyte along with the active encapsulated species. We found that the composites compressional strength decreased with an increasing volume percentage of hydrogel beads incorporated within the soap composite. Young's modulus showed a maximum when 7.5% by volume of hydrogel beads were used for composite preparation. These fast-dissolving soap–hydrogel composites contain significantly less raw materials and would reduce the pollution of waste water with surface active components. We envisage that soap–hydrogel bead composites could improve the sustainability of the soap-producing industry and could find their application within the hotel business, where they could reduce costs and the waste of millions of partially used soap bars discarded on a daily basis.

中文翻译：

智能肥皂：刺激响应的肥皂-水凝胶微珠复合材料，可控制活性物质的溶解和释放†

我们通过将不同尺寸分布的琼脂水凝胶微珠掺入到不同体积分数的熔融肥皂基质中来设计压力响应性肥皂-水凝胶微珠复合材料。冷却后，将水凝胶珠粒在熔融肥皂中的合并悬浮液置于肥皂基质的复合物中。我们证明了压缩后肥皂水凝胶珠粒复合物中水的压力驱动脱水收缩。通过在这些“智能”肥皂复合材料上施加压力，可以释放嵌入水凝胶珠粒中的活性成分。我们发现，这些复合材料的溶解速率通常随水凝胶珠粒的体积百分比而增加。我们获得的复合溶出速率比不含水凝胶珠粒的肥皂对照样品高约2.8倍。然而，复合物的溶解速率与包埋的水凝胶珠的大小无关。我们研究了封装在用于制备复合材料的水凝胶珠粒中的活性成分的释放速率。发现可以用三种不同方式控制释放速率：改变水凝胶珠粒的大小，使用用于制造水凝胶的不同浓度的胶凝聚合物，还可以通过将带相反电荷的聚电解质与活性被包封的物质一起共包封。我们发现，复合材料的抗压强度随着掺入肥皂复合材料中的水凝胶珠粒体积百分比的增加而降低。当将7.5％（体积）的水凝胶珠粒用于复合材料制备时，杨氏模量显示出最大值。这些快速溶解的肥皂水凝胶复合材料所含原材料少得多，可减少表面活性成分对废水的污染。我们设想，肥皂水凝胶珠复合物可以改善肥皂生产行业的可持续性，并可以在旅馆业中找到其应用，因为它们可以降低成本，并减少每天丢弃的数以百万计的部分使用过的肥皂的浪费。

更新日期：2018-01-16

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