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Resveratrol Potently Counteracts Quercetin Starvation‐Induced Autophagy and Sensitizes HepG2 Cancer Cells to Apoptosis
Molecular Nutrition & Food Research ( IF 5.2 ) Pub Date : 2018-02-22 , DOI: 10.1002/mnfr.201700610
Sarah Tomas-Hernández 1 , Jordi Blanco 2 , Cristina Rojas 1 , Joel Roca-Martínez 1 , María José Ojeda-Montes 1 , Raúl Beltrán-Debón 1 , Santiago Garcia-Vallvé 1, 3 , Gerard Pujadas 1, 3 , Lluís Arola 3, 4 , Miquel Mulero 1
Affiliation  

Resveratrol (RSV) has been described as a potent antioxidant, antisteatotic, and antitumor compound, and it has also been identified as a potent autophagy inducer. On the other hand, quercetin (QCT) is a dietary flavonoid with known antitumor, anti‐inflammatory, and antidiabetic effects. Additionally, QCT increases autophagy. To study the hypothetical synergistic effect of both compounds, we test the combined effect of QCT and RSV on the autophagy process in HepG2 cells.

中文翻译:

白藜芦醇有效地抵消槲皮素饥饿诱导的自噬,并使HepG2癌细胞凋亡。

白藜芦醇(RSV)被描述为有效的抗氧化剂,抗硬脂化和抗肿瘤化合物,还被鉴定为有效的自噬诱导剂。另一方面,槲皮素(QCT)是一种饮食类黄酮,具有已知的抗肿瘤,抗炎和抗糖尿病作用。另外,QCT增加了自噬。为了研究这两种化合物的假设协同作用,我们测试了QCT和RSV对HepG2细胞自噬过程的联合作用。
更新日期:2018-02-22
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