One hexanuclear Cu(I) cluster of 4,6-dimethylpyrimidine-2-thiolate efficiently catalyzes the dehydrogenative cross-coupling of secondary and primary alcohols to α-alkylated ketones with high selectivity. This transformation proceeds through a one-pot sequence of dehydrogenation of alcohols, condensation of aldehydes and ketones, hydrogenation of the resulting α,β-unsaturated ketones, and dehydrogenation of the α-alkylated alcohols to generate α-alkylated ketones. This catalytic system also displays high activity for the annulation reaction of secondary alcohols with γ-amino- and 2-aminobenzyl alcohols to yield pyridines and quinolines, respectively.

中文翻译：

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配体控制的铜（I）催化的仲醇和伯醇与α-烷基化酮，吡啶和喹啉的交叉偶联

一个4，6-二甲基嘧啶-2-硫醇盐的六核Cu（I）簇可以高选择性地催化仲醇和伯醇与α-烷基化酮的脱氢交叉偶联。通过一锅法进行醇的脱氢，醛和酮的缩合，所得的α，β-不饱和酮的氢化以及α-烷基化的醇的脱氢以生成α-烷基化的酮的顺序进行。该催化体系对于仲醇与γ-氨基和2-氨基苄醇的环化反应也分别显示出较高的活性，以分别产生吡啶和喹啉。