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Anxiolytic‐like effects of essential oil from Thymus vulgaris was increased during stress
Flavour and Fragrance Journal ( IF 2.1 ) Pub Date : 2018-01-15 , DOI: 10.1002/ffj.3434 Tadaaki Satou 1, 2 , Mako Hayakawa 3 , Yumi Goto 3 , Yoshinori Masuo 3 , Kazuo Koike 1
Flavour and Fragrance Journal ( IF 2.1 ) Pub Date : 2018-01-15 , DOI: 10.1002/ffj.3434 Tadaaki Satou 1, 2 , Mako Hayakawa 3 , Yumi Goto 3 , Yoshinori Masuo 3 , Kazuo Koike 1
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There is known to be a close relationship among anxiety, fatigue and stress. Here, we studied the anxiolytic‐like effects of essential oil from Thymus vulgaris (EOT), while focusing on the relationship with stress. Male ICR mice inhaled (i.h.) EOT for 90 min. Mice were placed under three different conditions; isolated, intraperitoneal (i.p.) administration of saline or polyinosinic‐polycytidylic acid (poly I:C). EOT did not show any significant anxiolytic‐like effects in isolated mice. On the other hand, in brain fatigue model mice by poly I:C, EOT showed significant anxiolytic‐like effects. EOT increased the absolute value in the elevated plus maze (EPM) tests in the brain fatigue model mice, while linalool and terpinen‐4‐ol in the brain with poly I:C were elevated when compared with isolated mice. Augmented concentrations of these components in the brain were also observed in mice with saline, i.p. These results suggest that the amount of volatile compounds transferred to the brain increased due to stress or inflammation. In the future, further investigation concerning the relationship between the blood brain barrier (BBB) and respiration is required.
中文翻译：
在压力下，来自百里香的精油的抗焦虑样作用增强了
焦虑，疲劳和压力之间有着密切的关系。在这里，我们研究了百里香的精油的抗焦虑样作用（EOT），同时着重强调与压力的关系。雄性ICR小鼠吸入（ih）EOT 90分钟。将小鼠置于三种不同条件下。腹膜内（ip）盐水或多肌苷-聚胞苷酸（poly I：C）的分离，腹膜内（ip）给药。EOT在离体小鼠中未显示任何明显的抗焦虑作用。另一方面，在通过poly I：C引起的脑疲劳模型小鼠中，EOT表现出明显的抗焦虑作用。与离体小鼠相比，EOT增加了大脑疲劳模型小鼠的高架迷宫（EPM）测试中的绝对值，而带有poly I：C的大脑中的芳樟醇和萜品醇4-醇增加了。在含生理盐水，ip的小鼠中也观察到脑中这些成分的浓度增加 这些结果表明，由于压力或炎症，转移到大脑的挥发性化合物的量增加了。将来，需要进一步研究血脑屏障（BBB）与呼吸之间的关系。
更新日期：2018-01-15
中文翻译：
在压力下，来自百里香的精油的抗焦虑样作用增强了
焦虑，疲劳和压力之间有着密切的关系。在这里，我们研究了百里香的精油的抗焦虑样作用（EOT），同时着重强调与压力的关系。雄性ICR小鼠吸入（ih）EOT 90分钟。将小鼠置于三种不同条件下。腹膜内（ip）盐水或多肌苷-聚胞苷酸（poly I：C）的分离，腹膜内（ip）给药。EOT在离体小鼠中未显示任何明显的抗焦虑作用。另一方面，在通过poly I：C引起的脑疲劳模型小鼠中，EOT表现出明显的抗焦虑作用。与离体小鼠相比，EOT增加了大脑疲劳模型小鼠的高架迷宫（EPM）测试中的绝对值，而带有poly I：C的大脑中的芳樟醇和萜品醇4-醇增加了。在含生理盐水，ip的小鼠中也观察到脑中这些成分的浓度增加 这些结果表明，由于压力或炎症，转移到大脑的挥发性化合物的量增加了。将来，需要进一步研究血脑屏障（BBB）与呼吸之间的关系。
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