Chagas disease, a chronic systemic parasitosis by the kinetoplastid protozoon Trypanosoma cruzi, is the leading cause of cardiac morbidity and mortality in poor rural and suburban areas of Latin America and the source of the largest parasitic disease burden in the American continent. This burden is now spreading worldwide owing to international migration.^1,2 A recent change in the scientific understanding of the pathogenesis of chronic Chagas disease has led to consensus that all T cruzi-seropositive patients should receive aetiological treatment with anti-T cruzi drugs.

中文翻译：

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通往安全，有效治疗慢性恰加斯病的漫长道路

南美锥虫病是一种由运动型原生动物克鲁斯锥虫引起的慢性全身性寄生虫病，是拉丁美洲贫困农村地区和郊区心脏病发病率和死亡率的主要原因，也是美洲大陆最大的寄生虫病负担源。由于国际移徙，这种负担现在正在全世界范围内蔓延。^1,2对慢性恰加斯病发病机理的科学认识的最新变化导致人们达成共识，即所有T克鲁兹血清阳性患者均应接受抗T克鲁兹药物的病因治疗。