Outcomes obtained with conventional chemotherapy treatments in patients with newly diagnosed acute lymphoblastic leukaemia worsen as age increases, with children displaying the most favourable end results and older patients the worst. Worse outcomes in older patients with acute lymphoblastic leukaemia are attributed to frequent presence of comorbidities, poor tolerance to intensive chemotherapy, and the different biological characteristics of acute lymphoblastic leukaemia at an older age, often displaying dissimilar patterns of sensitivity towards traditional chemotherapy agents.

中文翻译：

---

老年急性急性淋巴细胞性白血病患者的inotuzumab ozogamicin的研究前提和前景

新诊断的急性淋巴细胞白血病患者，随着年龄的增长，常规化学疗法的治疗效果会随着年龄的增长而恶化，儿童表现出最好的最终结果，而老年患者表现出最差的结果。老年急性淋巴细胞白血病患者的不良结局归因于合并症的频繁出现，对强化化疗的耐受性差以及老年急性淋巴细胞白血病的不同生物学特征，通常表现出对传统化疗药物敏感性不同的模式。