Physical Properties of Implanted Porous Bioscaffolds Regulate Skin Repair: Focusing on Mechanical and Structural Features,Advanced Healthcare Materials

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Physical Properties of Implanted Porous Bioscaffolds Regulate Skin Repair: Focusing on Mechanical and Structural Features
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2018-01-15 , DOI: 10.1002/adhm.201700894
Shumeng Jiang ₁ , Sabrina Cloud Li ₁ , Chenyu Huang ₂ , Barbara Pui Chan ₃ , Yanan Du ₁

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Porous bioscaffolds are applied to facilitate skin repair since the early 1990s, but a perfect regeneration outcome has yet to be achieved. Until now, most efforts have focused on modulating the chemical properties of bioscaffolds, while physical properties are traditionally overlooked. Recent advances in mechanobiology and mechanotherapy have highlighted the importance of biomaterials' physical properties in the regulation of cellular behaviors and regenerative processes. In skin repair, the mechanical and structural features of porous bioscaffolds are two major physical properties that determine therapeutic efficacy. Here, first an overview of natural skin repair with an emphasis on the major biophysically sensitive cell types involved in this multistage process is provided, followed by an introduction of the four roles of bioscaffolds as skin implants. Then, how the mechanical and structural features of bioscaffolds influence these four roles is discussed. The mechanical and structural features of porous bioscaffolds should be tailored to balance the acceleration of wound closure and functional improvements of the repaired skin. This study emphasizes that decoupling and precise control of the mechanical and structural features of bioscaffolds are significant aspects that should be considered in future biomaterial optimization, which can build a foundation to ultimately achieve perfect skin regeneration outcomes.

中文翻译：

植入的多孔生物支架的物理性质调节皮肤修复：专注于机械和结构特征

自1990年代初以来，就采用了多孔生物支架来促进皮肤修复，但尚未达到理想的再生效果。迄今为止，大多数努力都集中在调节生物支架的化学性质上，而传统上却忽略了物理性质。机械生物学和机械疗法的最新进展突显了生物材料的物理特性在调节细胞行为和再生过程中的重要性。在皮肤修复中，多孔生物支架的机械和结构特征是决定治疗功效的两个主要物理性质。在此，我们首先概述了自然的皮肤修复过程，重点介绍了此多阶段过程涉及的主要生物物理敏感细胞类型，随后介绍了生物支架作为皮肤植入物的四种作用。然后，讨论了生物支架的机械和结构特征如何影响这四个角色。应当调整多孔生物支架的机械和结构特征，以平衡伤口闭合的加速与修复后皮肤的功能改善之间的平衡。这项研究强调，生物支架的机械和结构特征的去耦和精确控制是未来生物材料优化中应考虑的重要方面，这可以为最终实现完美的皮肤再生结果奠定基础。应当调整多孔生物支架的机械和结构特征，以平衡伤口闭合的加速与修复后皮肤的功能改善之间的平衡。这项研究强调，生物支架的机械和结构特征的去耦和精确控制是未来生物材料优化中应考虑的重要方面，这可以为最终实现完美的皮肤再生结果奠定基础。应当调整多孔生物支架的机械和结构特征，以平衡伤口闭合的加速与修复后皮肤的功能改善之间的平衡。这项研究强调，生物支架的机械和结构特征的去耦和精确控制是未来生物材料优化中应考虑的重要方面，这可以为最终实现完美的皮肤再生结果奠定基础。

更新日期：2018-01-15

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