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Engineering Polymersomes for Diagnostics and Therapy
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2018-01-15 , DOI: 10.1002/adhm.201701276 Jiayu Leong 1, 2 , Jye Yng Teo 1, 2 , Vinay K Aakalu 3 , Yi Yan Yang 2 , Hyunjoon Kong 4
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2018-01-15 , DOI: 10.1002/adhm.201701276 Jiayu Leong 1, 2 , Jye Yng Teo 1, 2 , Vinay K Aakalu 3 , Yi Yan Yang 2 , Hyunjoon Kong 4
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Engineered polymer vesicles, termed as polymersomes, confer a flexibility to control their structure, properties, and functionality. Self‐assembly of amphiphilic copolymers leads to vesicles consisting of a hydrophobic bilayer membrane and hydrophilic core, each of which is loaded with a wide array of small and large molecules of interests. As such, polymersomes are increasingly being studied as carriers of imaging probes and therapeutic drugs. Effective delivery of polymersomes necessitates careful design of polymersomes. Therefore, this review article discusses the design strategies of polymersomes developed for enhanced transport and efficacy of imaging probes and therapeutic drugs. In particular, the article focuses on overviewing technologies to regulate the size, structure, shape, surface activity, and stimuli‐ responsiveness of polymersomes and discussing the extent to which these properties and structure of polymersomes influence the efficacy of cargo molecules. Taken together with future considerations, this article will serve to improve the controllability of polymersome functions and accelerate the use of polymersomes in biomedical applications.
中文翻译：
用于诊断和治疗的工程聚合物囊泡
工程聚合物囊泡（称为聚合物囊泡）赋予控制其结构、性质和功能的灵活性。两亲性共聚物的自组装产生由疏水性双层膜和亲水性核心组成的囊泡，每个囊泡都负载有各种感兴趣的小分子和大分子。因此，聚合物囊泡作为成像探针和治疗药物的载体越来越多地被研究。聚合物囊泡的有效递送需要仔细设计聚合物囊泡。因此，这篇综述文章讨论了为增强成像探针和治疗药物的运输和功效而开发的聚合物囊泡的设计策略。特别是，本文重点概述了调节聚合物囊泡的尺寸、结构、形状、表面活性和刺激响应性的技术，并讨论了聚合物囊泡的这些特性和结构对货物分子功效的影响程度。结合未来的考虑，本文将有助于提高聚合物囊泡功能的可控性，并加速聚合物囊泡在生物医学应用中的使用。
更新日期：2018-01-15
中文翻译：
用于诊断和治疗的工程聚合物囊泡
工程聚合物囊泡（称为聚合物囊泡）赋予控制其结构、性质和功能的灵活性。两亲性共聚物的自组装产生由疏水性双层膜和亲水性核心组成的囊泡，每个囊泡都负载有各种感兴趣的小分子和大分子。因此，聚合物囊泡作为成像探针和治疗药物的载体越来越多地被研究。聚合物囊泡的有效递送需要仔细设计聚合物囊泡。因此，这篇综述文章讨论了为增强成像探针和治疗药物的运输和功效而开发的聚合物囊泡的设计策略。特别是，本文重点概述了调节聚合物囊泡的尺寸、结构、形状、表面活性和刺激响应性的技术，并讨论了聚合物囊泡的这些特性和结构对货物分子功效的影响程度。结合未来的考虑，本文将有助于提高聚合物囊泡功能的可控性，并加速聚合物囊泡在生物医学应用中的使用。
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