Here the first nanomotor‐based strategy is reported to effectively cross tumor vasculature endothelium. The designed nanomotors are based on (poly(ethylene glycol)‐b‐polystyrene and poly(acrylic acid)‐b‐polystyrene) building blocks, which further self‐assemble into polymersomes of tunable sizes (100, 300 nm). The polymersomes are readily loaded with hydrophilic model drug into the aqueous compartment. A catalytic platinum cap is then partially deposited on the surface of the polymersome via electron beam evaporation, resulting in a polymersome Janus nanomotor. In a tumor vasculature model, these cargo‐loaded polymersome nanomotors demonstrate enhanced penetration across the endothelium.

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基于纳米马达的增强血管模型渗透性的策略

在这里，据报道，第一个基于纳米马达的策略有效地穿过了肿瘤血管内皮。设计的纳米马达基于（聚（乙二醇）-b-聚苯乙烯和聚（丙烯酸）-b-聚苯乙烯）构建基块，这些构建基块进一步自组装成可调大小（100、300 nm）的聚合物囊泡。聚合物囊泡很容易将亲水性模型药物装载到水性隔室中。然后通过电子束蒸发将催化铂帽部分沉积在聚合物囊泡的表面上，从而形成聚合物囊泡Janus纳米马达。在肿瘤脉管系统模型中，这些载有货物的多聚体纳米马达表现出增强的跨内皮渗透性。