A genome is a mosaic of chromosome fragments from ancestors who existed some arbitrary number of generations earlier. Here, we reconstruct the genome of Hans Jonatan (HJ), born in the Caribbean in 1784 to an enslaved African mother and European father. HJ migrated to Iceland in 1802, married and had two children. We genotyped 182 of his 788 descendants using single-nucleotide polymorphism (SNP) chips and whole-genome sequenced (WGS) 20 of them. Using these data, we reconstructed 38% of HJ's maternal genome and inferred that his mother was from the region spanned by Benin, Nigeria and Cameroon.

中文翻译：

---

重建 18 世纪的非洲单倍体基因组。


基因组是来自祖先的染色体片段的镶嵌体，这些祖先存在于任意几代之前。在这里，我们重建了汉斯·乔纳坦 (HJ) 的基因组，他于 1784 年出生于加勒比海，母亲是非洲奴隶，父亲是欧洲人。 HJ 于 1802 年移居冰岛，结婚并育有两个孩子。我们使用单核苷酸多态性 (SNP) 芯片对他的 788 个后代中的 182 个进行了基因分型，并对其中 20 个进行了全基因组测序 (WGS)。利用这些数据，我们重建了 HJ 38% 的母亲基因组，并推断他的母亲来自贝宁、尼日利亚和喀麦隆横跨的地区。