当前位置：
X-MOL 学术
›
Mater. Chem. Front.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Calcium ion-assisted lipid tubule formation†
Materials Chemistry Frontiers ( IF 6.0 ) Pub Date : 2018-01-15 00:00:00 , DOI: 10.1039/c7qm00521k Sandra Jones 1, 2, 3, 4 , An Huynh 1, 2, 3, 4 , Yuan Gao 1, 2, 3, 4 , Yan Yu 1, 2, 3, 4
Materials Chemistry Frontiers ( IF 6.0 ) Pub Date : 2018-01-15 00:00:00 , DOI: 10.1039/c7qm00521k Sandra Jones 1, 2, 3, 4 , An Huynh 1, 2, 3, 4 , Yuan Gao 1, 2, 3, 4 , Yan Yu 1, 2, 3, 4
Affiliation
|
Self-assembled lipid tubules are unique supramolecular structures in cell functions. Lipid tubules that are engineered in vitro are of great interest for technological applications ranging from the templated synthesis of nanomaterials to drug delivery. Herein, we report a study to create long lipid tubules from a mono-unsaturated lipid, 1-stearoyl-2-oleoyl-sn-glycero-3-phosphocholine (SOPC), due to the effect of calcium ions. We found that calcium ions at mM concentrations promote the self-assembly of SOPC lipids into inter-connected hollow lipid tubes that are μm thick and as long as a few millimeters. Higher calcium concentration leads to an increase in the numbers of lipid tubules formed, but has little effect on tubule diameter. Calcium ions also stabilize lipid tubules, which break up upon the removal of ions. We showed that the lipid tubule-promoting effect is general for divalent ions. We were able to vary the morphology of lipid tubules from thin tube to “strings of pearls” structures or increase the tubule thickness by mixing SOPC with other lipids of different spontaneous curvature effects. Our results reveal that the divalent charges of calcium ions and the asymmetric mono-unsaturated structure of SOPC acyl chains act in combination to cause the formation of lipid tubules.
中文翻译：
钙离子辅助脂质小管形成†
自组装脂质小管是细胞功能中独特的超分子结构。体外工程化的脂质小管对于从模板化的纳米材料合成到药物递送的技术应用引起了极大的兴趣。在此，我们报告了一项研究，该研究从单不饱和脂质1-stearoyl-2-oleoyl -sn-glycero创建长脂质小管-3-磷酸胆碱（SOPC），由于钙离子的作用。我们发现，mM浓度的钙离子促进SOPC脂质的自组装成相互连接的中空脂质管，该管的厚度为μm，长达几毫米。较高的钙浓度导致形成的脂质小管数目增加，但对小管直径影响很小。钙离子还可以稳定脂质小管，脂质小管在去除离子后会破裂。我们表明，脂质小管的促进作用一般适用于二价离子。通过将SOPC与其他具有不同自发曲率效应的脂质混合，我们能够将脂质小管的形态从细管改变为“珍珠串”结构，或增加肾小管的厚度。
更新日期：2018-01-15
中文翻译：
钙离子辅助脂质小管形成†
自组装脂质小管是细胞功能中独特的超分子结构。体外工程化的脂质小管对于从模板化的纳米材料合成到药物递送的技术应用引起了极大的兴趣。在此，我们报告了一项研究，该研究从单不饱和脂质1-stearoyl-2-oleoyl -sn-glycero创建长脂质小管-3-磷酸胆碱（SOPC），由于钙离子的作用。我们发现，mM浓度的钙离子促进SOPC脂质的自组装成相互连接的中空脂质管，该管的厚度为μm，长达几毫米。较高的钙浓度导致形成的脂质小管数目增加，但对小管直径影响很小。钙离子还可以稳定脂质小管，脂质小管在去除离子后会破裂。我们表明，脂质小管的促进作用一般适用于二价离子。通过将SOPC与其他具有不同自发曲率效应的脂质混合，我们能够将脂质小管的形态从细管改变为“珍珠串”结构，或增加肾小管的厚度。
京公网安备 11010802027423号