With the ever‐deeper understanding of nano–bio interactions and the development of fabrication methodologies of nanomaterials, various therapeutic platforms based on nanomaterials have been developed for next‐generation oncological applications, such as osteosarcoma therapy. In this work, a black phosphorus (BP) reinforced 3D‐printed scaffold is designed and prepared to provide a feasible countermeasure for the efficient localized treatment of osteosarcoma. The in situ phosphorus‐driven, calcium‐extracted biomineralization of the intra‐scaffold BP nanosheets enables both photothermal ablation of osteosarcoma and the subsequent material‐guided bone regeneration in physiological microenvironment, and in the meantime endows the scaffolds with unique physicochemical properties favoring the whole stepwise therapeutic process. Additionally, a corrugated structure analogous to Haversian canals is found on newborn cranial bone tissue of Sprague–Dawley rats, which may provide much inspiration for the future research of bone‐tissue engineering.

中文翻译：

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2D黑色磷强化3D打印支架：骨肉瘤的分步对策

随着对纳米生物相互作用的日益深入的了解以及纳米材料制造方法的发展，已经开发出了基于纳米材料的各种治疗平台，用于下一代肿瘤学应用，例如骨肉瘤治疗。在这项工作中，设计并准备了黑磷（BP）增强的3D打印支架，以为有效局部治疗骨肉瘤提供可行的对策。支架内BP纳米片的原位磷驱动钙提取生物矿化作用可实现骨肉瘤的光热消融以及随后在生理微环境中材料引导的骨再生，同时使支架具有独特的理化特性，从而有利于整体逐步的治疗过程。此外，