Systemic inflammation mediated by Plasmodium parasites is central to malaria disease and its complications. Plasmodium parasites reside in erythrocytes and can theoretically reach all host tissues via the circulation. However, actual interactions between parasitized erythrocytes and host tissues, along with the consequent damage and pathological changes, are limited locally to specific tissue sites. Such tissue specificity of the parasite can alter the outcome of malaria disease, determining whether acute or chronic complications occur. Here, we give an overview of the recent progress that has been made in understanding tissue-specific immunopathology during Plasmodium infection. As knowledge on tissue-specific host–parasite interactions accumulates, better treatment modalities and targets may emerge for intervention in malaria disease.

疟原虫寄生虫介导的全身性炎症是疟疾及其并发症的关键。疟原虫寄生虫存在于红细胞中，理论上可以通过循环到达所有宿主组织。然而，被寄生的红细胞与宿主组织之间的实际相互作用，以及随之而来的损害和病理变化，仅限于特定的组织部位。寄生虫的这种组织特异性可以改变疟疾疾病的结果，确定是否发生急性或慢性并发症。在这里，我们概述了在了解疟原虫期间组织特异性免疫病理学方面取得的最新进展。感染。随着有关组织特异性宿主-寄生虫相互作用的知识的积累，可能会出现更好的治疗方式和目标以干预疟疾。