Biocatalytic Synthesis of Nitriles through Dehydration of Aldoximes: The Substrate Scope of Aldoxime Dehydratases,ChemBioChem

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Biocatalytic Synthesis of Nitriles through Dehydration of Aldoximes: The Substrate Scope of Aldoxime Dehydratases
ChemBioChem ( IF 2.6 ) Pub Date : 2018-03-30 , DOI: 10.1002/cbic.201700571
Tobias Betke _{1,

2} , Jun Higuchi ₂ , Philipp Rommelmann ₁ , Keiko Oike ₁ , Taiji Nomura ₂ , Yasuo Kato ₂ , Yasuhisa Asano ₂ , Harald Gröger ₁

Affiliation

Tolerant enzymes: Nitriles are widely utilized by the chemical industry. Recently, an enzymatic approach to the synthesis of nitriles has been developed with aldoxime dehydratases, which catalyze the conversion of aldoximes into nitriles through dehydration. This review provides an overview of the enzyme properties and substrate scope for this method.