In this study, the impact of diclofenac (DCF), an antiinflammatory drug being extensively used in human health care and veterinary treatment, on the production of volatile fatty acids (VFAs) from anaerobic fermentation of waste activated sludge (WAS) was investigated for the first time. Experimental results showed that when DCF concentration increased from 2.5 to 25 mg/kg total suspended solid (TSS), the maximum production of VFAs increased from 599 to 1113 mg COD/L, but further increase of DCF to 47.5 mg/kg TSS decreased VFAs yield to 896 mg COD/L. The mechanism investigation revealed that DCF had no effect on the hydrolysis process, promoted the process of acidogenesis, acetogenesis, and homoacetogenesis, but severely inhibited methanogenesis, leading to the accumulation of VFAs. Microbial community analysis showed that the addition of DCF could promote the relative abundance of VFAs (especially acetic acid) producers, which was well consistent with the results obtained above.

在这项研究中，研究了双氯芬酸（DCF）（一种广泛用于人类医疗保健和兽医治疗的抗炎药）对废活性污泥（WAS）厌氧发酵产生挥发性脂肪酸（VFA）的影响。第一次。实验结果表明，当DCF浓度从2.5到25 mg / kg总悬浮固体（TSS）增加时，VFA的最大产量从599增加到1113 mg COD / L，但是DCF进一步增加到47.5 mg / kg TSS降低了VFAs产量为896 mg COD / L。机理研究表明，DCF对水解过程没有影响，促进了酸生成，产乙酸和同产乙酸的过程，但是严重抑制了甲烷生成，导致VFA的积累。