Hematopoiesis is regulated by signals from the microenvironment, transcription factor networks, and changes of the epigenetic landscape. Transcription factors interact with and shape chromatin to allow for lineage- and cell type-specific changes in gene expression. During B lymphopoiesis, epigenetic regulation is observed in multilineage progenitors in which a specific chromatin context is established, at the onset of the B cell differentiation when early B cell factor 1 (EBF1) induces lineage-specific changes in chromatin, during V(D)J recombination and after antigen-driven activation of B cells and terminal differentiation. In this review, we discuss the epigenetic changes underlying B cell differentiation, focusing on the role of transcription factor EBF1 in B cell lineage priming.

造血受来自微环境，转录因子网络和表观遗传环境变化的信号调节。转录因子与染色质相互作用并形成染色质，从而允许基因表达的谱系和细胞类型特异性变化。在B淋巴细胞生成过程中，在多谱系祖细胞中观察到表观遗传调控，其中特定的染色质背景已建立，在早期B细胞因子1（EBF1）在V（D）期间诱导B谱系特异性变化时，B细胞分化开始。J重组和抗原驱动后的B细胞活化和终末分化。在这篇综述中，我们讨论了B细胞分化的表观遗传学变化，重点是转录因子EBF1在B细胞谱系启动中的作用。