Energetic Costs, Precision, and Transport Efficiency of Molecular Motors,The Journal of Physical Chemistry Letters

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Energetic Costs, Precision, and Transport Efficiency of Molecular Motors
The Journal of Physical Chemistry Letters ( IF 4.8 ) Pub Date : 2018-01-17 00:00:00 , DOI: 10.1021/acs.jpclett.7b03197
Wonseok Hwang ₁ , Changbong Hyeon ₁

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An efficient molecular motor would deliver cargo to the target site at a high speed and in a punctual manner while consuming a minimal amount of energy. According to a recently formulated thermodynamic principle, referred to as the thermodynamic uncertainty relation, the travel distance of a motor and its variance are, however, constrained by the free energy being consumed. Here we use the principle underlying the uncertainty relation to quantify the transport efficiency of molecular motors for varying ATP concentration ([ATP]) and applied load (f). Our analyses of experimental data find that transport efficiencies of the motors studied here are semioptimized under the cellular condition. The efficiency is significantly deteriorated for a kinesin-1 mutant that has a longer neck-linker, which underscores the importance of molecular structure. It is remarkable to recognize that, among many possible directions for optimization, biological motors have evolved to optimize the transport efficiency in particular.

中文翻译：

分子电动机的能源成本，精度和运输效率

高效的分子电动机将以高速度，准时的方式将货物运送到目标位置，同时消耗最少的能量。根据最近制定的热力学原理（称为热力学不确定性关系），电动机的行进距离及其变化受消耗的自由能约束。在这里，我们使用不确定关系的基本原则来量化运输效率分子马达用于改变ATP浓度（[ATP]）和施加载荷（˚F）。我们对实验数据的分析发现，在蜂窝条件下，本文研究的电动机的运输效率是半优化的。对于具有较长颈部连接物的驱动蛋白1突变体，效率显着降低，这突显了分子结构的重要性。值得注意的是，在许多可能的优化方向中，生物马达已经发展为特别是优化运输效率。

更新日期：2018-01-17

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