Background

Few studies have evaluated the relationship between hidradenitis suppurativa (HS) and type 2 diabetes mellitus (T2DM), and the existing data show conflicting results.

Objective

To determine the prevalence of T2DM among patients with HS and identify at-risk demographic subgroups.

Methods

Cross-sectional analysis identifying T2DM among patients with and without HS from a demographically heterogeneous population-based sample of more than 50 million patients in the United States.

Results

The overall prevalence of T2DM among patients with HS was 24.8% (10,705 of 43,105) compared with 15.6% (1,993,320 of 12,527,570) among patients without HS. The prevalence was highest among patients with HS who were male (3045 of 10,785 [28.2%]), older (1945 of 3950 [49.2%]), nonwhite (4665 of 17,495 [26.7%]), obese (9065 of 30,855 [29.4%]), tobacco smokers (6880 of 25,005 [27.5%]), hypertensive (8595 of 19,610 [43.8%]), and hyperlipidemic (7965 of 17,190 [46.3%]). In univariable and multivariable analyses, patients with HS had 1.75 (95% confidence interval [CI], 1.71-1.79) and 1.58 (95% CI, 1.54-1.62) times the odds, respectively, of having T2DM. HS was associated with T2DM across all demographic subgroups. The association was stronger for younger patients (an OR of 1.67 and 95% CI of 1.60-1.72 for ages 18-44 years vs an OR of 1.50 and 95% CI of 1.41-1.61 for ages ≥65 years).

Limitations

We lacked information on HS disease severity.

Conclusion

Patients with HS with risk factors, signs, or symptoms of T2DM should be screened.

中文翻译：

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美国化脓性汗腺炎患者中2型糖尿病的患病率

背景

很少有研究评估化脓性汗腺炎（HS）与2型糖尿病（T2DM）之间的关系，现有数据显示出矛盾的结果。

客观的

为了确定HS患者中T2DM的患病率，并确定高危人群。

方法

横断面分析从美国超过5000万患者的人口统计学异质人群样本中识别出是否患有HS的患者中的T2DM。

结果

HS患者的T2DM总体患病率为24.8％（43,105人中的10,705），而HS患者中T2DM的整体患病率为15.6％（12,527,570中的1,993,320）。男性HS患者中患病率最高（10,785例中的3045例，占28.2％），老年人（3945例中的1945例，占39.2％[49.2％]），非白人（肥胖患者中的4665例，占17,495例[26.7％]），肥胖患者（9065例，占30,855例[29.4％]） ％），吸烟者（占25,005名中的6880名，占25.5％[27.5％]），高血压（占19,610名中的8595名，占[43.8％]）和高血脂症（占17190名中的7965名，占[46.3％]）。在单变量和多变量分析中，HS患者的T2DM几率分别为1.75（95％置信区间[CI]，1.71-1.79）和1.58（95％CI，1.54-1.62）。HS在所有人口统计学子组中均与T2DM相关。对于年轻患者而言，该关联性更强（18-44岁年龄组的OR为1.67，95％CI为1.60-1.72，而OR为1.50和95％CI为1。

局限性

我们缺乏有关HS疾病严重程度的信息。

结论

具有危险因素，体征或T2DM症状的HS患者应进行筛查。