Copper(II) ternary complex, [Cu(phen)(C-dmg)(H₂O)]NO₃ was evaluated against a panel of cell lines, tested for in vivo efficacy in nasopharyngeal carcinoma xenograft models as well as for toxicity in NOD scid gamma mice. The Cu(II) complex displayed broad spectrum cytotoxicity against multiple cancer types, including lung, colon, central nervous system, melanoma, ovarian, and prostate cancer cell lines in the NCI-60 panel. The Cu(II) complex did not cause significant induction of cytochrome P450 (CYP) 3A and 1A enzymes but moderately inhibited CYP isoforms 1A2, 2C9, 2C19, 2D6, 2B6, 2C8 and 3A4. The complex significantly inhibited tumor growth in nasopharyngeal carcinoma xenograft bearing mice models at doses which were well tolerated without causing significant or permanent toxic side effects. However, higher doses which resulted in better inhibition of tumor growth also resulted in toxicity.

铜（II）的三元复合物，[铜（phen）的（C-DMG）（H ₂ O）] NO ₃被抵抗的细胞系中评估，测试用于体内在鼻咽癌异种移植模型中的功效以及对NOD scidγ小鼠的毒性。Cu（II）复合物在NCI-60面板中显示出针对多种癌症类型的广谱细胞毒性，包括肺癌，结肠癌，中枢神经系统，黑色素瘤，卵巢癌和前列腺癌细胞系。Cu（II）复合物不会引起细胞色素P450（CYP）3A和1A酶的明显诱导，但会适度抑制CYP亚型1A2、2C9、2C19、2D6、2B6、2C8和3A4。该复合物以良好耐受的剂量显着抑制了携带鼻咽癌异种移植物的小鼠模型中的肿瘤生长，而不会引起显着或永久的毒副作用。然而，较高剂量导致对肿瘤生长的更好抑制也导致毒性。