Morphological and hemodynamic parameters have been suggested to affect the rupture of cerebral aneurysms, but detailed mechanisms of rupture are poorly understood. The purpose of our study is to determine criteria for predicting the risk of aneurysm rupture, which is critical for improved patient management. Existing aneurysm hemodynamics studies generally evaluate limited geometries or Reynolds numbers (Re), which are difficult to apply to a wide range of patient‐specific cases. Association between hemodynamic characteristics and morphology is focused. Several two‐dimensional (2D) and three‐dimensional (3D) idealized and physiological geometries is assessed to characterize the hemodynamic landscape between flow patterns. The impact of morphology on velocity and wall shear stress (WSS) profiles were evaluated. Slight changes in aneurysm geometry is found or Re result in significant changes in the hemodynamic and WSS profiles. Our systematic mapping and nondimensional analysis qualitatively identify hemodynamic conditions that may predispose aneurysms to rupture. © 2018 American Institute of Chemical Engineers AIChE J, 64: 2792–2802, 2018

中文翻译：

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基底动脉瘤的形态特征和雷诺数多样性对局部血流动力学的影响

形态学和血液动力学参数已被建议影响脑动脉瘤的破裂，但是破裂的详细机制却鲜为人知。我们研究的目的是确定预测动脉瘤破裂风险的标准，这对改善患者管理至关重要。现有的动脉瘤血流动力学研究通常会评估有限的几何形状或雷诺数（Re），很难将其应用于各种患者特定的病例。血液动力学特征和形态之间的关联是重点。对几个理想的二维（2D）和三维（3D）几何形状和生理几何形状进行了评估，以表征流型之间的血液动力学景观。评估了形态对速度和壁切应力（WSS）轮廓的影响。发现动脉瘤几何形状略有变化，或Re导致血液动力学和WSS曲线发生重大变化。我们的系统映射和无量纲分析定性地确定了可能导致动脉瘤破裂的血液动力学状况。©2018美国化学工程师学会AIChE J，64：2792–2802，2018